Computer modeling tools to understand the causes of preterm birth.
Computer modeling tools to understand the causes of preterm birth.
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DOI：
10.1053/j.semperi.2017.08.007
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发表时间：
2017-12
影响因子：
3.4
通讯作者：
Myers KM
中科院分区：
文献类型：
--
作者：
Westervelt AR;Myers KM
支持胎儿的软组织结构的机械完整性可能在维持健康怀孕和引发分娩方面发挥作用。目前，妊娠期间子宫、宫颈和胎膜上的机械负荷水平尚不清楚，推测这些组织的过度拉伸导致过早发生收缩、组织重塑和膜破裂，从而导致早产。这篇综述文章的目的是介绍和讨论工程分析工具来评估和预测子宫、宫颈和胎膜上的机械负荷。在这里，我们将探索利用计算生物力学和有限元分析来研究早产的原因，并开发一种可以预测妊娠结局的诊断工具的潜力。我们将定义工程学术语，并确定可能用于发出异常妊娠信号的潜在工程学变量。我们将讨论计算模型的翻译能力，以更好地管理临床患者。我们还将讨论模型验证的过程以及这些模型的局限性。我们将探索如何借鉴平行的工程领域来推动患者护理的边界，以便我们能够努力消除早产。
The mechanical integrity of the soft tissue structures supporting the fetus may play a role in maintaining a healthy pregnancy and triggering the onset of labor. Currently, the level of mechanical loading on the uterus, cervix, and fetal membranes during pregnancy is unknown, and it is hypothesized that the over-stretch of these tissues contributes to the premature onset of contractility, tissue remodeling, and membrane rupture, leading to preterm birth. The purpose of this review article is to introduce and discuss engineering analysis tools to evaluate and predict the mechanical loads on the uterus, cervix, and fetal membranes. Here we will explore the potential of using computational biomechanics and finite element analysis to study the causes of preterm birth and to develop a diagnostic tool that can predict gestational outcome. We will define engineering terms and identify the potential engineering variables that could be used to signal an abnormal pregnancy. We will discuss the translational ability of computational models for the better management of clinical patients. We will also discuss the process of model validation and the limitations of these models. We will explore how we can borrow from parallel engineering fields to push the boundary of patient care so that we can work toward eliminating preterm birth.
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影响因子：
7.2
作者：
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通讯作者：
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通讯作者：
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