Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.
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DOI：
10.1038/srep02229
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发表时间：
2013
影响因子：
4.6
通讯作者：
Scheer, Frank A. J. L.
中科院分区：
文献类型：
--
作者：
Hu, Kun;Harper, David G.;Shea, Steven A.;Stopa, Edward G.;Scheer, Frank A. J. L.
人类的运动活动有一种强健的内在分形结构，从几分钟到几小时都有相似的图案。这种分形活动模式似乎具有重要的生理意义，因为这种模式在不同的环境条件下仍然存在，但随着年龄的增长和阿尔茨海默病(AD)的出现，这种模式会显著改变/减少。在这里，我们报告了已知的扰乱昼夜节律的痴呆症患者也扰乱了分形活动模式，并且这种扰乱在淀粉样斑块(AD严重程度的标志)较多的患者中更加明显。此外，死亡后视交叉上核(SCN)内的加压素能神经元和神经张力能神经元(SCN)中的神经递质与分形活动的破坏程度密切相关，与传统的昼夜节律测量方法相比，它能更好地预测这两种神经递质的变化。这些发现表明，SCN在多个时间尺度上影响人类的活动调节，而破坏的分形活动可能是痴呆SCN神经退行性变的非侵入性生物标志物。
Human motor activity has a robust, intrinsic fractal structure with similar patterns from minutes to hours. The fractal activity patterns appear to be physiologically important because the patterns persist under different environmental conditions but are significantly altered/reduced with aging and Alzheimer's disease (AD). Here, we report that dementia patients, known to have disrupted circadian rhythmicity, also have disrupted fractal activity patterns and that the disruption is more pronounced in patients with more amyloid plaques (a marker of AD severity). Moreover, the degree of fractal activity disruption is strongly associated with vasopressinergic and neurotensinergic neurons (two major circadian neurotransmitters) in postmortem suprachiasmatic nucleus (SCN), and can better predict changes of the two neurotransmitters than traditional circadian measures. These findings suggest that the SCN impacts human activity regulation at multiple time scales and that disrupted fractal activity may serve as a non-invasive biomarker of SCN neurodegeneration in dementia.
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影响因子：
3.3
作者：
Hu, K.;Scheer, F. A. J. L.;Shea, S. A.
通讯作者：
Shea, S. A.
DOI：
10.1016/j.physa.2004.01.042
发表时间：
2004-06-01
影响因子：
3.3
作者：
Hu, K;Ivanov, PC;Shea, SA
通讯作者：
Shea, SA
影响因子：
4.2
作者：
Duffy, Jeanne F.;Zeitzer, Jamie M.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
--
作者：
Harper, DG;Stopa, EG;Volicer, L
通讯作者：
Volicer, L
DOI：
10.1523/jneurosci.0451-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Nakamura TJ;Nakamura W;Yamazaki S;Kudo T;Cutler T;Colwell CS;Block GD
通讯作者：
Block GD