A Whole-Body Musculoskeletal Model of the Mouse.
A Whole-Body Musculoskeletal Model of the Mouse.
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DOI：
10.1109/access.2021.3133078
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ijspeert AJ
中科院分区：
文献类型：
--
作者：
Ramalingasetty ST;Danner SM;Arreguit J;Markin SN;Rodarie D;Kathe C;Courtine G;Rybak IA;Ijspeert AJ
如果不仔细考虑神经和生物力学组件之间的相互作用，就不能完全理解神经对运动的控制。小鼠分子遗传学的最新进展使得识别和操纵神经控制运动的基本要素成为可能。为了补充实验研究，并研究神经回路与身体和环境相互作用的机制，模拟小鼠运动行为的计算研究需要纳入小鼠肌肉骨骼系统的模型。在这里，我们提出了第一个完全关节的小鼠肌肉骨骼模型。小鼠骨骼系统是从解剖学参考发展而来的，包括身体所有部分的骨骼，包括四肢、脊柱、头部和尾巴。所有骨骼之间的关节允许模拟完整的3D鼠标运动学和动力学。后肢和前肢肌肉是使用Hill类型的肌肉模型实现的。我们分析了小鼠全身模型，描述了不同后肢和前肢肌肉的力臂，这些肌肉施加在关节上的力矩，以及它们在不同肢体/身体构型下参与肢体运动的情况。该模型代表了随后发展自由行为小鼠的全面神经生物力学模型的必要步骤；这将关闭神经控制和身体与环境之间的物理交互之间的循环。
Neural control of movement cannot be fully understood without careful consideration of interactions between the neural and biomechanical components. Recent advancements in mouse molecular genetics allow for the identification and manipulation of constituent elements underlying the neural control of movement. To complement experimental studies and investigate the mechanisms by which the neural circuitry interacts with the body and the environment, computational studies modeling motor behaviors in mice need to incorporate a model of the mouse musculoskeletal system. Here, we present the first fully articulated musculoskeletal model of the mouse. The mouse skeletal system has been developed from anatomical references and includes the sets of bones in all body compartments, including four limbs, spine, head and tail. Joints between all bones allow for simulation of full 3D mouse kinematics and kinetics. Hindlimb and forelimb musculature has been implemented using Hill-type muscle models. We analyzed the mouse whole-body model and described the moment-arms for different hindlimb and forelimb muscles, the moments applied by these muscles on the joints, and their involvement in limb movements at different limb/body configurations. The model represents a necessary step for the subsequent development of a comprehensive neuro-biomechanical model of freely behaving mice; this will close the loop between the neural control and the physical interactions between the body and the environment.
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影响因子：
3.7
作者：
Charles JP;Cappellari O;Spence AJ;Hutchinson JR;Wells DJ
通讯作者：
Wells DJ
影响因子：
2.5
作者：
Ekeberg, O;Pearson, K
通讯作者：
Pearson, K
影响因子：
5.6
作者：
Ausborn J;Shevtsova NA;Danner SM
通讯作者：
Danner SM
影响因子：
25
作者：
Cregg JM;Leiras R;Montalant A;Wanken P;Wickersham IR;Kiehn O
通讯作者：
Kiehn O
影响因子：
2.4
作者：
Charles JP;Cappellari O;Spence AJ;Wells DJ;Hutchinson JR
通讯作者：
Hutchinson JR