The application of functional magnetic resonance imaging in an infant rat model of irritable bowel syndrome.
The application of functional magnetic resonance imaging in an infant rat model of irritable bowel syndrome.
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DOI：
10.1155/2014/473846
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发表时间：
2014
影响因子：
2
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Zhu X;Zhu X;Chen W;Chen J
本研究的目的是利用功能磁共振成像（BOLD-fMRI）研究IBS模型幼鼠脑内与内脏痛相关的激活区域。将16只新生大鼠随机分为IBS模型组和对照组。IBS组与母亲分离，机械制动，用芥末精油直肠致敏1周。对照组不做任何处理。2周后，两组的直肠内球囊导管膨胀5或10 mL的空气。行BOLD-fMRI检查，图像分析软件进行分析。在IBS模型组中，直肠刺激5 mL空气扩张激活了前扣带皮层、前额叶皮层（PFC）、前扣带皮层（IC）和丘脑，而10 mL空气刺激显著激活了模型组中的ACC、IC、PFC和丘脑，而对照组则没有。IBS模型组对直肠球囊扩张内脏刺激过敏。参与内脏感觉的主要脑区包括IC、PFC和丘脑。
The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week. The control group had no treatment. After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups. BOLD-fMRI was performed and the data analyzed by imaging software. In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls. IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation. The major brain areas participating in visceral sensation included the IC, PFC, and thalamus.
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