Functional Hyperconnectivity during a Stories Listening Task in Magnetoencephalography Is Associated with Language Gains for Children Born Extremely Preterm.
Functional Hyperconnectivity during a Stories Listening Task in Magnetoencephalography Is Associated with Language Gains for Children Born Extremely Preterm.
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脑磁图中听故事任务中的功能超连接与极早产儿的语言获得相关。
DOI：
10.3390/brainsci11101271
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发表时间：
2021-09-26
期刊：
影响因子：
3.3
通讯作者：
Kadis DS
中科院分区：
文献类型：
--
作者：
Barnes-Davis ME;Fujiwara H;Drury G;Merhar SL;Parikh NA;Kadis DS
极端早产（EPT，小于28周妊娠）与语言问题有关。我们以前曾报道过使用脑磁图（MEG）在EPT儿童与足月儿童（TC）中的超连接。在这里，我们的目标是确定功能超连接是否是EPT儿童语言弹性的标志，验证我们早期的工作与当代表现良好的EPT和早产儿与语言延迟（EPT-HLD）的历史的一个独特的样本。共有58名儿童（17名EPT，9名EPT-HLD和32名TC）在4-6岁时参加了MEG和功能磁共振成像（fMRI）期间的故事听。我们比较了EPT和EPT-HLD的连接性，研究了随着时间的推移与语言的关系。我们在听故事的过程中测量了fMRI激活，并将激活图进行分组以获得用于MEG连接分析的“节点”。在年龄、性别、种族、民族、父母教育程度、收入、语言得分或功能磁共振成像上的语言表征方面没有显著的组间差异。MEG功能连接（加权相位滞后指数）组间差异显著。早产儿增加了连接性，复制了我们早期的工作。EPT和EPT-HLD在24-26 Hz下与TC相比具有超连接性，其中EPT-HLD表现出最大的连接性。从2岁到4-6岁，网络强度与标准化分数的变化相关，这表明超连接是促进语言发展的标志。
Extreme prematurity (EPT, <28 weeks gestation) is associated with language problems. We previously reported hyperconnectivity in EPT children versus term children (TC) using magnetoencephalography (MEG). Here, we aim to ascertain whether functional hyperconnectivity is a marker of language resiliency for EPT children, validating our earlier work with a distinct sample of contemporary well-performing EPT and preterm children with history of language delay (EPT-HLD). A total of 58 children (17 EPT, 9 EPT-HLD, and 32 TC) participated in stories listening during MEG and functional magnetic resonance imaging (fMRI) at 4–6 years. We compared connectivity in EPT and EPT-HLD, investigating relationships with language over time. We measured fMRI activation during stories listening and parcellated the activation map to obtain “nodes” for MEG connectivity analysis. There were no significant group differences in age, sex, race, ethnicity, parental education, income, language scores, or language representation on fMRI. MEG functional connectivity (weighted phase lag index) was significantly different between groups. Preterm children had increased connectivity, replicating our earlier work. EPT and EPT-HLD had hyperconnectivity versus TC at 24–26 Hz, with EPT-HLD exhibiting greatest connectivity. Network strength correlated with change in standardized scores from 2 years to 4–6 years of age, suggesting hyperconnectivity is a marker of advancing language development.
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影响因子：
11.2
作者：
Ball G;Aljabar P;Nongena P;Kennea N;Gonzalez-Cinca N;Falconer S;Chew ATM;Harper N;Wurie J;Rutherford MA;Counsell SJ;Edwards AD
通讯作者：
Edwards AD
DOI：
10.1097/dbp.0b013e3181e5ab7e
发表时间：
2010-10-01
影响因子：
2.4
作者：
Foster-Cohen, Susan H.;Friesen, Myron D.;Woodward, Lianne J.
通讯作者：
Woodward, Lianne J.
影响因子：
5.7
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
通讯作者：
Ment, Laura R.
影响因子：
5.7
作者：
Batalle D;Hughes EJ;Zhang H;Tournier JD;Tusor N;Aljabar P;Wali L;Alexander DC;Hajnal JV;Nosarti C;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
影响因子：
5.1
作者：
Barre, Natalie;Morgan, Angela;Anderson, Peter J.
通讯作者：
Anderson, Peter J.