Higher brain functions served by the lowly rodent primary visual cortex.
Higher brain functions served by the lowly rodent primary visual cortex.
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DOI：
10.1101/lm.034355.114
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Bear MF
中科院分区：
文献类型：
--
作者：
Gavornik JP;Bear MF
自从第一次描述眼优势可塑性以来，已经有50多年了--暂时性单眼剥夺后初级视觉皮质(V1)的深刻改变。这一发现立即引起了神经生物学家的浓厚兴趣，他们专注于这样一个普遍问题：经历和剥夺如何改变大脑，使其成为学习和记忆的潜在底物。近年来，随着小鼠成为研究视觉皮质可塑性的首选物种，发现的步伐大大加快，新的研究推翻了初级感觉皮质在发育关键期后是一成不变的教条。最近的研究表明，除了眼优势可塑性外，成人视皮层还表现出几种形式的反应调节，以前被认为是高级皮质区域的专属区域。这些“高级大脑功能”包括刺激熟悉度的神经报告、奖励时间预测和时空序列学习。初级视觉皮质不再被视为具有在早期发育过程中确定的静态属性的简单视觉特征检测器。啮齿动物V1是一个丰富而动态的皮质区域，在这个区域中，通常只与“高级”大脑区域相关的功能可以在机械水平上进行研究。
It has been more than 50 years since the first description of ocular dominance plasticity—the profound modification of primary visual cortex (V1) following temporary monocular deprivation. This discovery immediately attracted the intense interest of neurobiologists focused on the general question of how experience and deprivation modify the brain as a potential substrate for learning and memory. The pace of discovery has quickened considerably in recent years as mice have become the preferred species to study visual cortical plasticity, and new studies have overturned the dogma that primary sensory cortex is immutable after a developmental critical period. Recent work has shown that, in addition to ocular dominance plasticity, adult visual cortex exhibits several forms of response modification previously considered the exclusive province of higher cortical areas. These “higher brain functions” include neural reports of stimulus familiarity, reward-timing prediction, and spatiotemporal sequence learning. Primary visual cortex can no longer be viewed as a simple visual feature detector with static properties determined during early development. Rodent V1 is a rich and dynamic cortical area in which functions normally associated only with “higher” brain regions can be studied at the mechanistic level.
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影响因子：
16.2
作者：
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