The effect of ketamine on eye movement characteristics during free-viewing of natural images in common marmosets.
The effect of ketamine on eye movement characteristics during free-viewing of natural images in common marmosets.
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氯胺酮在公共果蝇中自由图中的自由图像期间对眼动特性的影响。
DOI：
10.3389/fnins.2022.1012300
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发表时间：
2022
影响因子：
4.3
通讯作者：
Yoshida, Masatoshi
中科院分区：
文献类型：
--
作者：
Polyakova, Zlata;Iwase, Masao;Hashimoto, Ryota;Yoshida, Masatoshi
精神分裂症患者有各种眼动异常和视觉信息处理障碍的报道。因此，跳眼运动功能障碍是精神分裂症的潜在生物学标志。在本研究中，我们使用了狨猴精神分裂症症状的药理学模型，并使用与人类研究相同的图像集，比较了狨猴在自由观看时的眼球运动特征。它包含自然和复杂的图像，随机呈现8秒。作为精神分裂症症状的药理学模型，亚麻醉剂量的氯胺酮肌内注射进行短暂和可逆的操作。在氯胺酮和生理盐水的对照条件下，记录眼球运动并进行比较。结果表明，氯胺酮会影响自由观看时的眼球运动特征。在氯胺酮的作用下，眼跳振幅和扫描路径长度明显减少。此外，氯胺酮组的扫视持续时间比生理盐水组长。在注视的持续时间中也观察到类似的趋势。在氯胺酮的作用下，扫视次数和注视次数有减少的趋势。注射氯胺酮后，眼跳峰值速度也有所下降，但眼跳振幅与眼跳峰值速度的主序关系无显著差异。这些结果表明氯胺酮影响了狨猴的视觉探索，但不影响扫视的眼动方面，这与精神分裂症患者的研究一致。因此，我们得出结论，亚麻醉剂量氯胺酮是一种很有希望的普通狨猴精神分裂症症状的药理学模型，可以与自由观察范式结合使用，建立灵长类精神分裂症的“可翻译标记”。
Various eye movement abnormalities and impairments in visual information processing have been reported in patients with schizophrenia. Therefore, dysfunction of saccadic eye movements is a potential biological marker for schizophrenia. In the present study, we used a pharmacological model of schizophrenia symptoms in marmosets and compared the eye movement characteristics of marmosets during free-viewing, using an image set identical to those used for human studies. It contains natural and complex images that were randomly presented for 8 s. As a pharmacological model of schizophrenia symptoms, a subanesthetic dose of ketamine was injected intramuscularly for transient and reversible manipulation. Eye movements were recorded and compared under a ketamine condition and a saline condition as a control. The results showed that ketamine affected eye movement characteristics during free-viewing. Saccades amplitude and scanpath length were significantly reduced in the ketamine condition. In addition, the duration of saccades was longer under the ketamine condition than under the saline condition. A similar tendency was observed for the duration of fixations. The number of saccades and fixations tended to decrease in the ketamine condition. The peak saccades velocity also decreased after ketamine injection whereas there was no difference in the main sequence relationship between saccades amplitude and peak velocity. These results suggest that ketamine affected visual exploration but did not affect the oculomotor aspect of saccades in marmosets, consistent with studies in patients with schizophrenia. Therefore, we conclude that the subanesthetic dose of ketamine is a promising pharmacological model of schizophrenia symptoms in common marmosets and can be used in combination with free-viewing paradigms to establish “translatable markers” for schizophrenia in primates.
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影响因子：
5.9
作者：
Kaneko T;Komatsu M;Yamamori T;Ichinohe N;Okano H
通讯作者：
Okano H
影响因子：
5.3
作者：
Hung, Chia-Chun;Yen, Cecil C.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1109/34.730558
发表时间：
1998-11-01
影响因子：
23.6
作者：
Itti, L;Koch, C;Niebur, E
通讯作者：
Niebur, E
影响因子：
6.6
作者：
Campana, A;Duci, A;Scarone, S
通讯作者：
Scarone, S