Clinical study on the treatment of chronic wound with negatively-charged aerosol.
Clinical study on the treatment of chronic wound with negatively-charged aerosol.
复制标题
负电气雾剂治疗慢性创面的临床研究
DOI：
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复制
发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Xie X, Chen L, Zhang ZQ, Shi Y, Xie J
中科院分区：
文献类型：
--
作者：
Xie X, Chen L, Zhang ZQ, Shi Y, Xie J
背景
气溶胶被定义为稳定悬浮在空气中的液体或固体颗粒/液滴的混合物。当携带一定量的负电荷时，它们将被定义为带负电荷的气溶胶。本文研究了负电荷气雾剂对慢性创面愈合的影响。
方法
将140例慢性创面患者随机分为两组。73例慢性创面根据创面情况进行常规治疗（对照组）。另67例相同的患者接受负压雾化治疗，每次2 h，每日2次，作为实验组。伤口愈合评估包括患者并发症、伤口分泌物细菌检测和伤口愈合评估。
结果
结果表明，实验组应用负电荷气雾剂后，创面愈合情况好于对照组，感染率低于对照组。与对照组相比，实验组在治疗后第0、7、14、21和28天的伤口相对大小显著较小（P<0.05）。实验组创面愈合时间明显短于对照组（P<0.05）。
结论
负电荷气雾剂治疗可加快创面愈合速度，促进慢性创面愈合。因此，我们建议在慢性伤口的情况下，除了正常的伤口治疗外，还应考虑使用带负电荷的气雾剂治疗。
BACKGROUND
Aerosols are defined as the mixture of liquid or solid particles/droplets that are stably suspending in air. When carrying a certain amount of negative charge, they will be defined as negatively-charged aerosol. This report investigates the effect of negatively-charged aerosol on the healing of chronic wound.
METHODS
140 patients with chronic wound were assigned randomly into two groups. Normal, routine treatment was applied on chronic wounds of 73 patients depending on wounds situation (control group). While another 67 similar patients received negatively-charged aerosol therapy (2 hours per time, twice a day) and were used as experimental group. Wound healing assessment including the patients' complication, detection of bacteria in wound secretions, and evaluation of wound healing.
RESULTS
The results of our study showed that after the application of negatively-charged aerosols, and condition and infection rate of wounds from experiment group were better and lower than that of control group. In comparison with control group, the relative size of wounds from experiment group was significantly smaller (P<0.05) at post-treatment day 0, 7, 14, 21 and 28. Also, the time required for wound healing in the experimental group was significantly shorter (P<0.05) than that in the control group.
CONCLUSION
Negatively-charged aerosol therapy can accelerate wound healing speed and improve the healing of chronic wounds. Thus, we wound recommend the consideration of Negatively-charged aerosol therapies in addition to normal wound treatment in cases of chronic wound.
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DOI：
10.3181/00379727-101-24997
发表时间：
1959-07
影响因子：
--
作者：
A. P. Krueger;R. F. Smith;J. Millar
通讯作者：
A. P. Krueger;R. F. Smith;J. Millar
DOI：
10.1080/10934520801959831
发表时间：
2008-04
期刊：
Journal of Environmental Science and Health, Part A
影响因子：
--
作者：
A. Tyagi;B. Nirala;A. Malik;Kamlesh Singh
通讯作者：
A. Tyagi;B. Nirala;A. Malik;Kamlesh Singh
影响因子：
38.9
作者：
Kerr, KG;Beggs, CB;Taylor, CC
通讯作者：
Taylor, CC
影响因子：
2.9
作者：
Lazarus, Gerald S.;Cooper, Diane M.;Robson, Martin C.
通讯作者：
Robson, Martin C.
影响因子：
56.9
作者：
KRUEGER, AP;REED, EJ
通讯作者：
REED, EJ