Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China.
Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China.
复制标题
DOI：
10.1080/22221751.2022.2088407
复制
发表时间：
2022-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
--
作者：
携带进化枝2.3.4.4b血凝素基因的H5 N1禽流感病毒已在野生鸟类中广泛传播，自2020年10月以来，已导致欧洲、非洲、亚洲和北美超过7000万只家禽死亡。在我们的常规监测期间，从2021年9月至2022年3月在中国收集的26，767份野鸟和家禽样本中分离出13种H5 N1病毒。为了调查这些中国分离株的来源，并了解它们与全球流行的H5 N1病毒的遗传关系，我们对从28个国家分离的233株代表性H5 N1病毒株进行了详细的基因分析。我们发现，H5 N1病毒在荷兰出现后，与野鸟中流行的不同病毒进行了复杂的基因交换，形成了16种基因型。基因型1（G1）占主导地位，在22个国家检测到，而所有其他基因型仅在一个或两个大陆检测到。在中国检测到四种基因型（G1、G7、G9和G10）的H5 N1病毒;其中三种基因型以前曾在其他国家报告过。在中国检测到的H5 N1病毒在小鼠中复制，不同毒株的致病性不同; G1病毒在小鼠中具有高度致死性。此外，我们发现这些病毒与中国目前使用的H5-Re 14疫苗株抗原性相似且匹配良好。我们的研究揭示了H5 N1病毒进化的全貌，并为控制这些病毒提供了见解。
H5N1 avian influenza viruses bearing the clade 2.3.4.4b hemagglutinin gene have been widely circulating in wild birds and are responsible for the loss of over 70 million domestic poultry in Europe, Africa, Asia, and North America since October 2020. During our routine surveillance, 13 H5N1 viruses were isolated from 26,767 wild bird and poultry samples that were collected between September 2021 and March 2022 in China. To investigate the origin of these Chinese isolates and understand their genetic relationship with the globally circulating H5N1 viruses, we performed a detailed phylogenic analysis of 233 representative H5N1 strains that were isolated from 28 countries. We found that, after they emerged in the Netherlands, the H5N1 viruses encountered complicated gene exchange with different viruses circulating in wild birds and formed 16 genotypes. Genotype one (G1) was predominant, being detected in 22 countries, whereas all other genotypes were only detected in one or two continents. H5N1 viruses of four genotypes (G1, G7, G9, and G10) were detected in China; three of these genotypes have been previously reported in other countries. The H5N1 viruses detected in China replicated in mice, with pathogenicity varying among strains; the G1 virus was highly lethal in mice. Moreover, we found that these viruses were antigenically similar to and well matched with the H5-Re14 vaccine strain currently used in China. Our study reveals the overall picture of H5N1 virus evolution and provides insights for the control of these viruses.
登录
查看更多内容
影响因子：
3.7
作者：
Fan, Shufang;Deng, Guohua;Chen, Hualan
通讯作者：
Chen, Hualan
影响因子：
5.4
作者：
Feng X;Wang Z;Shi J;Deng G;Kong H;Tao S;Li C;Liu L;Guan Y;Chen H
通讯作者：
Chen H
影响因子：
6.7
作者：
Li X;Shi J;Guo J;Deng G;Zhang Q;Wang J;He X;Wang K;Chen J;Li Y;Fan J;Kong H;Gu C;Guan Y;Suzuki Y;Kawaoka Y;Liu L;Jiang Y;Tian G;Li Y;Bu Z;Chen H
通讯作者：
Chen H
影响因子：
5.4
作者：
Ayllon J;Domingues P;Rajsbaum R;Miorin L;Schmolke M;Hale BG;García-Sastre A
通讯作者：
García-Sastre A
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ