PTSD and depression severity are associated with cardiovascular disease symptoms in trauma-exposed women.
PTSD and depression severity are associated with cardiovascular disease symptoms in trauma-exposed women.
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DOI：
10.1080/20008066.2023.2234810
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发表时间：
2023
影响因子：
5
通讯作者：
Seligowski AV
中科院分区：
文献类型：
--
作者：
Noble NC;Merker JB;Webber TK;Ressler KJ;Seligowski AV
背景：创伤后应激障碍（PTSD）和抑郁症与心血管疾病（CVD）的风险增加有关，心血管疾病是全球死亡和残疾的主要原因。流行病学研究表明，这些疾病是高度合并症，特别是在妇女中。在目前的研究中，我们探讨了在出生时被指定为女性的创伤暴露个体样本中心血管健康、创伤后应激障碍和抑郁指标之间的关系。方法：参与者为N = 49例无心血管疾病且报告终生标准A创伤暴露的个体。静息5分钟时采集血压（BP）、心率（HR）和高频心率变异性（HF-HRV）。评估心血管疾病的症状（如四肢疼痛和肿胀、呼吸急促）、创伤后应激障碍和抑郁，同时对快感缺乏进行探索性测量。结果：创伤暴露与收缩压呈正相关(r =。32、p =。029)和舒张压(r =。30, p = .040)。报告的心血管疾病症状数量与PTSD症状呈正相关(r =。41、p =。004)，抑郁(r =。40, p =。005)和快感缺乏症(r =。38, p = .007)。CVD症状也与PTSD显著相关(β =。41, t = 2.43, p =。023)，抑郁(β =。40, t = 2.76, p =。009)，快感缺乏(β =。38, t = 2.51, p =。017)在控制年龄和创伤暴露后。在我们的样本中，这些关联没有被HF-HRV缓和。结论：我们的研究结果支持PTSD与抑郁症状和心血管功能恶化之间的联系，这些联系在经常被忽视的人群中尤其容易受到这些疾病的影响。未来的研究应该调查创伤后应激障碍和抑郁症治疗对创伤暴露个体，特别是女性心血管疾病风险的残余影响。创伤暴露和创伤后应激障碍与抑郁症和心血管疾病（CVD）风险相关。我们研究了49名出生时被指定为女性的创伤暴露个体的心血管健康、创伤后应激障碍和抑郁症。创伤暴露与血压呈正相关。心血管疾病症状与创伤后应激障碍、抑郁和快感缺乏呈正相关。这种关联不受心率变异性的影响。
Background: Posttraumatic stress disorder (PTSD) and depression are associated with increased risk for cardiovascular disease (CVD), which is the leading cause of death and disability worldwide. Epidemiological studies have revealed these illnesses to be highly comorbid, particularly among women. In the current study, we explored associations between indices of cardiovascular health, PTSD, and depression among a sample of trauma-exposed individuals assigned female at birth. Methods: Participants were N = 49 individuals without CVD who reported lifetime Criterion A trauma exposure. Blood pressure (BP), heart rate (HR), and high-frequency heart rate variability (HF-HRV) were collected during a 5-minute resting period. Symptoms of CVD (e.g. extremity pain and swelling, shortness of breath), PTSD, and depression were assessed, along with an exploratory measure of anhedonia. Results: Trauma exposure was positively correlated with systolic BP (r = .32, p = .029) and diastolic BP (r = .30, p = .040). The number of reported CVD symptoms was positively correlated with symptoms of PTSD (r = .41, p = .004), depression (r = .40, p = .005) and anhedonia (r = .38, p = .007). CVD symptoms were also significantly associated with PTSD (β = .41, t = 2.43, p = .023), depression (β = .40, t = 2.76, p = .009), and anhedonia (β = .38, t = 2.51, p = .017) after controlling for age and trauma exposure. These associations were not moderated by HF-HRV in our sample. Conclusions: Our results support the association between PTSD and depressive symptoms and worse cardiovascular functioning among an often-overlooked population that is particularly vulnerable to these illnesses. Future studies should investigate residual impacts of PTSD and depression treatment on CVD risk among trauma-exposed individuals, particularly women. Trauma exposure and PTSD are associated with depression and cardiovascular disease (CVD) risk. We explored cardiovascular health, PTSD, and depression among 49 trauma-exposed individuals assigned female at birth. Trauma exposure positively correlated with blood pressure. CVD symptoms were positively correlated with PTSD, depression, and anhedonia. Associations were not moderated by heart rate variability.
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