Effects of Unilateral Arm Warming or Cooling on the Modulation of Brachial Artery Shear Stress and Endothelial Function during Leg Exercise in Humans.
Effects of Unilateral Arm Warming or Cooling on the Modulation of Brachial Artery Shear Stress and Endothelial Function during Leg Exercise in Humans.
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DOI：
10.5551/jat.55731
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发表时间：
2021-03-01
影响因子：
4.4
通讯作者：
Fukuba Y
中科院分区：
文献类型：
--
作者：
Miura K;Kashima H;Morimoto M;Namura S;Yamaoka Endo M;Oue A;Fukuba Y
目的：我们研究了运动期间使用前臂加热和冷却来调节切应力（SS）分布对肱动脉（BA）后续内皮功能的影响。研究方法：12名健康年轻受试者在120-130 bpm的腿部自行车运动中将右前臂浸入水中（15°C或42°C）60 min。使用多普勒超声同时记录BA直径和血流速度，以评估运动前、运动中和运动后的顺行、逆行和平均剪切率（SR，SS的估计值）。在运动前（基线）和运动后15分钟和60分钟，使用二维高分辨率超声检查，使用血流介导的扩张（FMD）（%）评价右BA的内皮功能。结果如下：在运动过程中，与对照试验相比，在温暖试验中观察到更高的顺行和平均SR和更低的逆行SR;相反，在凉爽试验中观察到更低的顺行和平均SR和更高的逆行SR。在运动后15分钟，在温暖试验（Δ%FMD：+1.6%，增加趋势; p = 0.08）和对照试验（Δ %FMD：+1.1%）中未观察到FMD较基线的显著变化。然而，在凉爽试验中，运动后60分钟的FMD较基线下降（Δ%FMD：-2.7%），低于温暖试验（Δ%FMD：+1.5%）和对照试验（Δ%FMD：+1.2%）。运动期间和运动后每个SR的累积变化与运动后FMD变化显著相关。结论：运动过程中BA剪切曲线的调节似乎与随后的内皮功能相关。
Aim: We examined the effect of modulating the shear stress (SS) profile using forearm warming and cooling on subsequent endothelial function in the brachial artery (BA) during exercise. Methods: Twelve healthy young subjects immersed their right forearm in water (15°C or 42°C) during a leg cycling exercise at 120–130 bpm for 60 min. The same exercise without water immersion served as a control. The BA diameter and blood velocity were simultaneously recorded using Doppler ultrasonography to evaluate the antegrade, retrograde, and mean shear rates (SRs, an estimate of SS) before, during, and after exercise. The endothelial function in the right BA was evaluated using flow-mediated dilation (FMD) (%) using two-dimensional high-resolution ultrasonography before (baseline) and 15 and 60 min after exercise. Results: During exercise, compared with the control trial, higher antegrade and mean SRs and lower retrograde SRs were observed in the warm trial; conversely, lower antegrade and mean SRs and higher retrograde SRs were observed in the cool trial. At 15 min postexercise, no significant change was observed in the FMD from baseline in the warm (Δ%FMD: +1.6%, tendency to increase; p = 0.08) and control trials (Δ %FMD: +1.1%). However, in the cool trial, the postexercise FMD at 60 min decreased from baseline (Δ%FMD: −2.7%) and was lower than that of the warm (Δ%FMD: +1.5%) and control (Δ%FMD: +1.2%) trials. Accumulated changes in each SR during and after exercise were significantly correlated with postexercise FMD changes. Conclusion: Modulation of shear profiles in the BA during exercise appears to be associated with subsequent endothelial function.
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影响因子：
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作者：
McClean C;Harris RA;Brown M;Brown JC;Davison GW
通讯作者：
Davison GW
DOI：
10.1152/ajpheart.91491.2007
发表时间：
2008-05-01
影响因子：
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发表时间：
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影响因子：
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影响因子：
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