High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls.
High Ghrelin Level Predicts the Curve Progression of Adolescent Idiopathic Scoliosis Girls.
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高生长素释放肽水平可预测青春期特发性脊柱侧弯女孩的曲线进展
DOI：
10.1155/2018/9784083
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发表时间：
2018
影响因子：
--
通讯作者：
Wang YJ
中科院分区：
文献类型：
--
作者：
Yu HG;Zhang HQ;Zhou ZH;Wang YJ
背景青少年特发性脊柱侧凸(AIS)是常见的原因不明的畸形。已有研究提示AIS女童血清瘦素和Ghrelin水平异常。本研究的目的是评估血清瘦素和Ghrelin水平是否可以作为预测AIS女孩曲线进展的危险因素。并探讨了它们与体格特征之间的关系。材料与方法采用双抗体夹心酶联免疫吸附试验检测105例AIS女童和40例非AIS女童的外周血瘦素和Ghrelin水平。分析AIS组Ghrelin、Leptin水平与生长相关参数(年龄、体重、矫正身高、矫正BMI、主要Cobb角、Risser征)的相关性。采用多因素Logistic回归分析AIS女孩曲线型进展的预测因素。结果AIS患者血清瘦素水平(6.5 5±2.88vs.8.0 1±3.12 ng/ml，P<0.0 5)和Ghrelin水平(6.33±2.46，4.46±2.0 2 ng/ml，P<0.0 5)明显低于正常对照组。曲线组Ghrelin水平(7.6 1±2.48vs.5.5 4±2.11 ng/ml，P<0.0 1)高于曲线组(P<0.0 1)，Leptin水平在曲线组与稳定组之间无显著差异。多因素Logistic逐步回归分析结果显示，初潮前状态、初始主干Cobb分级大于或等于23°、高Ghrelin水平(≥7.30 ng/ml)和低Risser分级(0~2级)是预测弯曲度进展的危险因素。Ghrelin水平为6.48 ng/ml预测曲线进展的敏感性为70.00%，特异性为72.31%，曲线下面积为0.741(95%可信区间0.646~0.821)。结论高Ghrelin水平可作为预测AIS女童弯曲度进展的一个新的定量指标。
Background Adolescent idiopathic scoliosis (AIS) is common deformity with unknown cause. Previous studies have suggested the abnormal serum leptin and ghrelin level in AIS girls. The aim of present study was to evaluate whether the serum leptin and ghrelin level could serve as risk factor in predicting the curve progression in AIS girls. The associations between them and the physical characteristics were also investigated. Materials and Methods Circulating leptin and ghrelin levels from 105 AIS girls and 40 age-matched non-AIS girls were examined by enzyme-linked immunosorbent assay. The correlations between ghrelin and leptin levels and growth-related parameters (age, weight, corrected height, corrected BMI, main Cobb angle, and Risser sign) were analyzed in AIS group. Multivariate logistic regression was used to investigate factors predicting curve progression in AIS girls. Results A significantly lower leptin level (6.55 ± 2.88 vs. 8.01 ± 3.12 ng/ml, p < 0.05) and a higher ghrelin level (6.33 ± 2.46 vs. 4.46 ± 2.02 ng/ml, p < 0.05) were found in all AIS patients, as compared with normal controls. Curve progression patients had a higher ghrelin level than stable curve patients (7.61 ± 2.48 vs. 5.54 ± 2.11 ng/ml, p < 0.01); for leptin level, there was no significant difference between progression and stable group. The results of multivariate logistic stepwise regression showed that premenarche status, initial main Cobb magnitude that was more than or equal to 23°, high ghrelin level (≥7.30 ng/ml), and lower Risser grade (grades 0 to 2) were identified as risk factors in predicting curve progression. Ghrelin levels of >6.48 ng/ml were predictive for curve progression with 70.00 % sensitivity and 72.31 % specificity, and the area under the curve (AUC) was 0.741 (95 % confidence interval 0.646-0.821). Conclusions High ghrelin level may serve as a new quantitative indicator for predicting curve progression in AIS girls.
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影响因子：
2.3
作者：
Busscher I;Wapstra FH;Veldhuizen AG
通讯作者：
Veldhuizen AG
DOI：
10.1186/1748-7161-1-2
发表时间：
2006-03-31
期刊：
Scoliosis
影响因子：
--
作者：
Asher MA;Burton DC
通讯作者：
Burton DC
影响因子：
3.2
作者：
Delporte C
通讯作者：
Delporte C
影响因子：
3
作者：
Tan, Ken-Jin;Moe, Maung Maung;Wong, Hee-Kit
通讯作者：
Wong, Hee-Kit
影响因子：
3
作者：
Lowe, T;Lawellin, D;O'Brien, M
通讯作者：
O'Brien, M