Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer.
Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer.
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DOI：
10.1038/sj.bjc.6603923
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发表时间：
2007-10-08
影响因子：
8.8
通讯作者：
Popel, A. S.
中科院分区：
文献类型：
--
作者：
Kut, C.;Mac Gabhann, F.;Popel, A. S.
血管内皮生长因子（VEGF）是抑制肿瘤血管形成和治疗人类癌症的主要靶标。许多肿瘤产生大量的VEGF，因此，可以通过测量血液中VEGF浓度的变化来预测癌症的诊断和预后。在血液中，VEGF可以位于血浆中，或位于血液携带的细胞和有形成分中，特别是血小板和白细胞。在这项研究中，我们整理了乳腺癌，前列腺癌，结直肠癌和其他癌症的血小板，白细胞，血浆和血清中VEGF的测量结果。此外，我们分析了肿瘤组织本身以及人体其他组织中VEGF的浓度。虽然肿瘤中VEGF的浓度很高，但与其他组织（特别是骨骼肌）相比，肿瘤的大小很小。因此，肿瘤和血液中VEGF的总量与肌肉中的量相比很小。这种VEGF的大储存库可能对癌症的治疗具有重要意义。
Vascular endothelial growth factor (VEGF) is a major target for the inhibition of tumour vascularisation and the treatment of human cancer. Many tumours produce large quantities of VEGF, and as a result, diagnosis and prognosis of cancer may be predicted by measuring changes in VEGF concentrations in blood. In blood, the VEGF may be located in the plasma, or in the blood-borne cells and formed elements, in particular, platelets and leukocytes. In this study, we collate the measurements of VEGF in platelets, leukocytes, plasma and serum for breast, prostate, colorectal and other cancers. In addition, we analysed the concentration of VEGF in tumour tissue itself, as well as for other tissues in the human body. Although the concentration of VEGF in tumours is high, the size of tumours is small compared to other tissues, in particular, skeletal muscle. Thus, the total quantity of VEGF in tumours and in blood is small compared to the quantity in muscles. This large reservoir of VEGF may have important implications for the treatment of cancer.
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影响因子：
8.8
作者：
Eisen T;Boshoff C;Mak I;Sapunar F;Vaughan MM;Pyle L;Johnston SR;Ahern R;Smith IE;Gore ME
通讯作者：
Gore ME
影响因子：
8.8
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通讯作者：
Berthois, Y
影响因子：
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作者：
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通讯作者：
Blann, AD