Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment.
Leukocyte/platelet hybrid membrane-camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment.
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白细胞/血小板杂化膜伪装树突状大孔介孔二氧化硅纳米粒子共载光/化疗药物用于三阴性乳腺癌联合治疗
DOI：
10.1016/j.bioactmat.2021.04.004
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发表时间：
2021-11
影响因子：
18.9
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhang T;Liu H;Li L;Guo Z;Song J;Yang X;Wan G;Li R;Wang Y
三阴性乳腺癌（TNBC）是乳腺癌的一个侵袭性亚组，目前缺乏有效的治疗靶点。光热疗法（Photothermal Therapy，PTT）和光动力疗法（Photodynamic Therapy，PDT）作为两种主要的光治疗方法，在TNBC治疗中显示出诸多优势，二者联合化疗可达到协同治疗效果。本研究基于白细胞/血小板杂化膜（LPHM）和树枝状大孔介孔硅纳米粒子（DLMSNs）构建了一种仿生纳米平台。将近红外（NIR）荧光染料IR 780和化疗药物阿霉素（DOX）共负载到DLMSNs的大孔中以制备DLMSN@DOX/IR 780（DDI）纳米颗粒（NPs），随后用LPHM进行伪装以获得LPHM@DDI NPs。通过LPHM的介导，LPHM@DDI纳米粒在体外和体内均表现出良好的TNBC靶向性和极高的PTT/PDT性能。在NIR激光照射下，LPHM@DDI NPs在TNBC细胞中表现出协同的细胞毒性和肿瘤诱导活性，并通过肿瘤消融和抗血管生成有效抑制TNBC小鼠中的肿瘤生长和复发。这些协同作用来源于PTT/PDT与化疗的联合。总而言之，本研究提供了一种有前途的仿生纳米平台，用于TNBC组合治疗的光/化疗剂的有效共负载和靶向递送。以白细胞/血小板杂化膜包裹的DLMSNs（LPHM@DLMSNs）为材料，构建了一种仿生纳米平台。将IR 780和多柔比星共负载到LPHM@ DLMSN中以制备LPHM@DDI纳米颗粒（NP）。LPHM@DDI纳米颗粒对三阴性乳腺癌（TNBC）显示出优异的靶向能力。LPHM@DDI NPs对PTT/PDT和化疗对TNBC具有协同作用。
Triple-negative breast cancer (TNBC) is an aggressive subset of breast cancer and currently lacks effective therapeutic targets. As two main phototherapeutic methods, photothermal therapy (PTT) and photodynamic therapy (PDT) show many advantages in TNBC treatment, and their combination with chemotherapy can achieve synergistic therapeutic effects. In the present study, a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane (LPHM) and dendritic large pore mesoporous silicon nanoparticles (DLMSNs). A near infrared (NIR) fluorescent dye IR780 and a chemotherapeutic drug doxorubicin (DOX) were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780 (DDI) nanoparticles (NPs), followed by camouflage with LPHM to obtain LPHM@DDI NPs. Through the mediation of LPHM, LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances in vitro and in vivo. Upon NIR laser irradiation, LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and anti-angiogenesis. These synergistic effects were sourced from the combination of PTT/PDT and chemotherapy. Altogether, this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment. A biomimetic nanoplatform was developed from DLMSNs camouflaged with leukocyte/platelet hybrid membrane (LPHM@DLMSNs). IR780 and doxorubicin were co-loaded into LPHM@DLMSNs to prepare LPHM@DDI nanoparticles (NPs). LPHM@DDI NPs showed an excellent targeting ability for triple negative breast cancer (TNBC). LPHM@DDI NPs exerted synergistic effects of PTT/PDT and chemotherapy against TNBC.
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