Maternal intake of pesticide residues from fruits and vegetables in relation to fetal growth.
Maternal intake of pesticide residues from fruits and vegetables in relation to fetal growth.
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DOI：
10.1016/j.envint.2018.07.014
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发表时间：
2018-10
影响因子：
11.8
通讯作者：
Chavarro JE
中科院分区：
文献类型：
--
作者：
Chiu YH;Williams PL;Gillman MW;Hauser R;Rifas-Shiman SL;Bellavia A;Fleisch AF;Oken E;Chavarro JE
研究母亲摄入水果和蔬菜（FV），考虑农药残留水平，与胎儿生长的关联。我们研究了1777名母亲（1275名白色，502名非白色）和他们的婴儿从Viva项目，一个前瞻性的出生前队列（1999-2002年）。我们使用美国农业部的数据将FV分为高或低农药残留。然后，我们使用食物频率问卷来估计每个参与者在第一和第二个三个月的高和低农药残留的FV摄入量。主要结局为小于胎龄儿（SGA;小于胎龄儿出生体重第10百分位数）、大于胎龄儿（LGA;大于胎龄儿出生体重第10百分位数）和早产（胎龄<37周）。我们还评估了高农药残留FV摄入量和出生结局之间的关联是否受种族/民族的影响。5.5%的新生儿为SGA，13.7%为LGA，7.3%为早产。高或低农药残留FV的摄入量，无论怀孕三个月，与SGA，LGA或早产的风险无关。此外，高农药FV摄入量与SGA和LGA的关联未被种族/民族修改。然而，我们观察到妊娠早期高农药FV摄入量与早产风险之间的关系存在异质性（相互作用的P值=0.01），尽管这种关系在多重比较校正后并不持续（Bonferroni校正的显著性水平：P < 2.8×l0−3）。在怀孕期间高或低农药FV摄入量与SGA，LGA或早产之间没有明显的关联。
To examine the associations of maternal intake of fruits and vegetables (FVs), considering pesticide residue levels, with fetal growth. We studied 1777 mothers (1275 white, 502 non-white) and their infants from Project Viva, a prospective pre-birth cohort (1999-2002). We categorized FVs as containing high or low pesticide residues using data from the US Department of Agriculture. We then used a food frequency questionnaire to estimate each participant’s intake of high and low pesticide residue FVs in the first and second trimester. The primary outcomes were small-for-gestational-age (SGA; < 10th percentile in birth-weight-for-gestational-age), large-for-gestational-age (LGA; ≥ 10th percentile in birth-weight-for-gestational-age) and preterm birth (gestational age <37 weeks). We also evaluated whether the associations between high pesticide residue FV intake and birth outcomes were modified by race/ethnicity. 5.5% of newborns were SGA, 13.7% were LGA, and 7.3% were preterm. Intakes of high or low pesticide residue FVs, regardless of pregnancy trimester, were not associated with risks of SGA, LGA, or preterm birth. In addition, the associations of high pesticide FV intake with SGA and LGA were not modified by race/ethnicity. However, we observed heterogeneity in the relationship between first trimester high pesticide FV intake and risk of preterm birth by race/ethnicity (P value for interaction=0.01), although this relationship did not persist after correction for multiple comparisons (Bonferroni corrected level of significance: P < 2.8×l0−3). There were no clear associations between high or low pesticide FV intake during pregnancy with SGA, LGA or preterm birth.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
副氧酶1（PON1）是对有机磷酸盐毒性易感性的遗传决定因素。
影响因子：
4.5
作者：
Costa, Lucio G.;Giordano, Gennaro;Cole, Toby B.;Marsillach, Judit;Furlong, Clement E.
通讯作者：
Furlong, Clement E.
影响因子：
1.9
作者：
Fall CH;Fisher DJ;Osmond C;Margetts BM;Maternal Micronutrient Supplementation Study Group
通讯作者：
Maternal Micronutrient Supplementation Study Group
影响因子：
10.4
作者：
Brantsaeter, Anne Lise;Torjusen, Hanne;Haugen, Margaretha
通讯作者：
Haugen, Margaretha
影响因子：
39
作者：
Chiu YH;Williams PL;Gillman MW;Gaskins AJ;Mínguez-Alarcón L;Souter I;Toth TL;Ford JB;Hauser R;Chavarro JE;EARTH Study Team
通讯作者：
EARTH Study Team