Prognostic value of patient-reported quality of life for survival in oesophagogastric cancer: analysis from the population-based POCOP study.
Prognostic value of patient-reported quality of life for survival in oesophagogastric cancer: analysis from the population-based POCOP study.
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DOI：
10.1007/s10120-021-01209-1
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Dutch Upper GI Cancer Group (DUCG)
中科院分区：
文献类型：
--
作者：
van Kleef JJ;Dijksterhuis WPM;van den Boorn HG;Prins M;Verhoeven RHA;Gisbertz SS;Slingerland M;Mohammad NH;Creemers GJ;Neelis KJ;Heisterkamp J;Rosman C;Ruurda JP;Kouwenhoven EA;van de Poll-Franse LV;van Oijen MGH;Sprangers MAG;van Laarhoven HWM;Dutch Upper GI Cancer Group (DUCG)
越来越多的试验证据表明，患者在确诊时报告的健康相关生活质量(HRQOL)是食道癌总生存率(OS)的预后。然而，缺乏真实世界的数据。此外，疾病阶段和肿瘤特有症状的差异通常不被考虑在内。这项以人群为基础的研究的目的是评估包括肿瘤特异性评分在内的HRQOL对潜在可治愈和晚期食道癌患者OS的预后价值。数据来自荷兰癌症登记处和患者报告结果登记处(POCOP)。2016至2018年间纳入POCOP的患者被分层为潜在可治愈(CT1-4aNallM0)或晚期(cT4b或CM1)疾病。使用EORTC QLQ-C30和肿瘤特异性OG25模块测量HRQOL。COX比例风险模型评估了HRQL、社会人口学和临床因素(包括治疗)对OS的影响。总共有924名患者纳入研究。潜在可治愈患者的中位OS为38.9个月(n = 795)，晚期疾病患者的中位OS为10.6个月(n = 129)。全球健康状况与潜在可治愈患者的OS独立相关(HR 0.89，99%CI 0.82-0.97)，以及其他几个HRQOL项目：食欲不振、吞咽困难、进食限制、吞咽疼痛和身体形象。在晚期疾病中，综合评分是最强的独立预后因素(HR 0.75，99%CI 0.59~0.94)，其次是疲劳、疼痛、失眠和角色功能。在现实生活中，HRQOL是潜在可治愈和晚期食道癌患者OS的预后指标。几个HRQL域，包括总结评分和几个OG25条目，可以用来开发或更新预后模型。网上版载有补充材料，可在10.1007/s10120-021-01209-1查阅。
Accumulating evidence of trials demonstrates that patient-reported health-related quality of life (HRQoL) at diagnosis is prognostic for overall survival (OS) in oesophagogastric cancer. However, real-world data are lacking. Moreover, differences in disease stages and tumour-specific symptoms are usually not taken into consideration. The aim of this population-based study was to assess the prognostic value of HRQoL, including tumour-specific scales, on OS in patients with potentially curable and advanced oesophagogastric cancer. Data were derived from the Netherlands Cancer Registry and the patient reported outcome registry (POCOP). Patients included in POCOP between 2016 and 2018 were stratified for potentially curable (cT1-4aNallM0) or advanced (cT4b or cM1) disease. HRQoL was measured with the EORTC QLQ-C30 and the tumour-specific OG25 module. Cox proportional hazards models assessed the impact of HRQoL, sociodemographic and clinical factors (including treatment) on OS. In total, 924 patients were included. Median OS was 38.9 months in potentially curable patients (n = 795) and 10.6 months in patients with advanced disease (n = 129). Global Health Status was independently associated with OS in potentially curable patients (HR 0.89, 99%CI 0.82–0.97), together with several other HRQoL items: appetite loss, dysphagia, eating restrictions, odynophagia, and body image. In advanced disease, the Summary Score was the strongest independent prognostic factor (HR 0.75, 99%CI 0.59–0.94), followed by fatigue, pain, insomnia and role functioning. In a real-world setting, HRQoL was prognostic for OS in patients with potentially curable and advanced oesophagogastric cancer. Several HRQoL domains, including the Summary Score and several OG25 items, could be used to develop or update prognostic models. The online version contains supplementary material available at 10.1007/s10120-021-01209-1.
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影响因子：
45.3
作者：
Mauer, Murielle E. L.;Taphoorn, Martin J. B.;van den Bent, Martin J.
通讯作者：
van den Bent, Martin J.
影响因子：
51.1
作者：
Quinten, Chantal;Coens, Corneel;Bottomley, Andrew
通讯作者：
Bottomley, Andrew
影响因子：
7.6
作者：
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Ruth, M.
影响因子：
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作者：
Giesinger, Johannes M.;Kieffer, Jacobien M.;Aaronson, Neil K.
通讯作者：
Aaronson, Neil K.
DOI：
10.6004/jnccn.2020.7579
发表时间：
2020-10-01
影响因子：
13.4
作者：
Mackay, Tara M.;Latenstein, Anouk E. J.;van Laarhoven, Hanneke W. M.
通讯作者：
van Laarhoven, Hanneke W. M.