Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in Michigan.
Environmental risk factors and amyotrophic lateral sclerosis (ALS): a case-control study of ALS in Michigan.
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DOI：
10.1371/journal.pone.0101186
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Feldman EL
中科院分区：
文献类型：
--
作者：
Yu Y;Su FC;Callaghan BC;Goutman SA;Batterman SA;Feldman EL
为探讨环境因素在肌萎缩侧索硬化（ALS）发病中的作用，进行了一项病例对照研究的中期报告。招募了66名病例和66名年龄和性别匹配的对照。通过问卷调查获得有关居住史、职业史、吸烟、体力活动和其他因素的详细信息。ALS与潜在的危险因素，包括吸烟，体力活动和化学品暴露的关联，使用条件logistic回归模型进行了研究。与对照组相比，在过去30年中，我们随机选择的ALS患者中有更多的人报告暴露于肥料以治疗私人庭院和花园以及职业暴露于农药。当将随机选择的ALS患者与对照组进行比较时，吸烟、职业性金属暴露、灰尘/纤维/烟雾/气体和辐射以及体力活动与ALS无关。为了进一步探索和确认结果，考虑了几个时间范围内的暴露，包括0-10年和10-30年前，并按年龄和性别进行分层分析。在随机选择的ALS患者中，农药和化肥暴露与ALS显著相关。虽然研究结果需要谨慎解释，因为样本量小，缺乏直接暴露措施，这些结果表明，环境，特别是住宅暴露因素值得密切关注的研究检查ALS的危险因素。
An interim report of a case-control study was conducted to explore the role of environmental factors in the development of amyotrophic lateral sclerosis (ALS). Sixty-six cases and 66 age- and gender-matched controls were recruited. Detailed information regarding residence history, occupational history, smoking, physical activity, and other factors was obtained using questionnaires. The association of ALS with potential risk factors, including smoking, physical activity and chemical exposure, was investigated using conditional logistic regression models. As compared to controls, a greater number of our randomly selected ALS patients reported exposure to fertilizers to treat private yards and gardens and occupational exposure to pesticides in the last 30 years than our randomly selected control cases. Smoking, occupational exposures to metals, dust/fibers/fumes/gas and radiation, and physical activity were not associated with ALS when comparing the randomly selected ALS patients to the control subjects. To further explore and confirm results, exposures over several time frames, including 0–10 and 10–30 years earlier, were considered, and analyses were stratified by age and gender. Pesticide and fertilizer exposure were both significantly associated with ALS in the randomly selected ALS patients. While study results need to be interpreted cautiously given the small sample size and the lack of direct exposure measures, these results suggest that environmental and particularly residential exposure factors warrant close attention in studies examining risk factors of ALS.
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影响因子：
10.4
作者：
Brown, Rebecca C;Lockwood, Alan H;Sonawane, Babasaheb R
通讯作者：
Sonawane, Babasaheb R
影响因子：
9.9
作者：
ARMON, C;KURLAND, LT;OBRIEN, PC
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OBRIEN, PC
影响因子：
3.5
作者：
GIAGHEDDU, M;PUGGIONI, G;RACHELE, MG
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RACHELE, MG
影响因子：
5.4
作者：
Johansen, C
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Johansen, C
影响因子：
9.9
作者：
BHARUCHA, NE;SCHOENBERG, BS;MASON, TJ
通讯作者：
MASON, TJ