T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.

T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.
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DOI:
10.1002/acn3.51653
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发表时间:
2023-11
影响因子:
5.3
通讯作者:
Struck, Aaron F.
Struck, Aaron F.
中科院分区:
医学2区
文献类型:
--
作者:
Denis, Colin;Dabbs, Kevin;Nair, Veena A.;Mathis, Jedidiah;Almane, Dace N.;Lakshmanan, Akshayaa;Nencka, Andrew;Birn, Rasmus M.;Conant, Lisa;Humphries, Colin;Felton, Elizabeth;Raghavan, Manoj;Deyoe, Edgar A.;Binder, Jeffrey R.;Hermann, Bruce;Prabhakaran, Vivek;Bendlin, Barbara B.;Meyerand, Mary E.;Boly, Melanie;Struck, Aaron F.

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颞叶癫痫(TLE)患者边缘系统网络的短程功能连接增加,最近的研究表明皮质髓鞘含量与功能磁共振成像连接相关。因此,我们假设髓鞘可能在癫痫网络中逐渐增加。我们比较了TLE患者和年龄匹配的对照组之间的T1 w/T2 w灰质髓鞘图,并评估了髓鞘和衰老之间的关系。虽然TLE患者和健康对照组均表现出T1 w/T2 w强度随年龄增加而增加,但我们没有发现TLE中总体髓鞘含量或髓鞘随时间变化的显著组水平畸变的证据。
Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.
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