Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites.
Nanoparticle-based laser desorption/ionization mass spectrometric analysis of drugs and metabolites.
复制标题
DOI：
10.1016/j.jfda.2018.07.001
复制
发表时间：
2018-10
影响因子：
3.6
通讯作者：
Huang, Chih-Ching
中科院分区：
文献类型：
--
作者：
Chu, Han-Wei;Unnikrishnan, Binesh;Anand, Anisha;Mao, Ju-Yi;Huang, Chih-Ching
纳米颗粒辅助激光解吸/电离质谱（LDI-MS）是一种分析各种分子的强大工具。应用纳米材料作为基质和基体，可以避免基质辅助激光解吸/电离质谱（MALDI-MS）中的许多缺点，实现低m/z区域的低背景噪声和高重现性。表面辅助LDI-MS（SALDI-MS），尤其是基于纳米颗粒的LDI-MS，由于其高的分析物富集表面积、高效的解吸/电离和样品的均匀结晶，已成为分析各种生物样品中痕量物质的一种有前途的技术。因此，它在临床、法医学、医学、食品和药物分析、疾病诊断和各种其他领域中非常有用。本文简要介绍了金属基、碳基、硅基纳米材料和纳米复合材料在LDI-MS药物和代谢物分析中的基质和底物应用以及可能的检测策略。此外，我们还讨论了使用纳米颗粒辅助LDI-MS进行药物和代谢物检测的信号放大的想法。
Nanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region and high reproducibility. Surface-assisted LDI (SALDI)-MS, especially the nanoparticle-based LDI-MS, has emerged as a promising technique for the analysis of trace amounts of substances in various biological samples due to their high surface area for analyte enrichment, efficient desorption/ionization, and homogeneous crystallization of sample. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields. In this review, we briefly discuss the application of various nanomaterials, which include metal-based, carbon-based, silicon-based nanomaterials and nanocomposites, as matrices and substrates for LDI-MS based drug and metabolite analyses and possible detection strategies. Also, we discuss the idea of using “mass tag” for signal amplification for drug and metabolite detection using nanoparticle assisted LDI-MS.
登录
查看更多内容
用于药物和代谢物检测的等离子银纳米壳
影响因子：
16.6
作者：
Huang L;Wan J;Wei X;Liu Y;Huang J;Sun X;Zhang R;Gurav DD;Vedarethinam V;Li Y;Chen R;Qian K
通讯作者：
Qian K
影响因子：
15
作者：
Gulbakan B;Yasun E;Shukoor MI;Zhu Z;You M;Tan X;Sanchez H;Powell DH;Dai H;Tan W
通讯作者：
Tan W
影响因子：
2
作者：
Gustafsson, O. J. R.;Guinan, T. M.;Voelcker, N. H.
通讯作者：
Voelcker, N. H.
影响因子：
2.2
作者：
Benton, M.;Chua, M. J.;Ma, J.
通讯作者：
Ma, J.
影响因子：
1.7
作者：
Benton, Matthew;Rowell, Frederick;Jan, Ma
通讯作者：
Jan, Ma