Molecular Control of Follicular Helper T cell Development and Differentiation.
Molecular Control of Follicular Helper T cell Development and Differentiation.
复制标题
滤泡辅助 T 细胞发育和分化的分子控制
DOI：
10.3389/fimmu.2018.02470
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发表时间：
2018
影响因子：
7.3
通讯作者：
Lu Q
中科院分区：
文献类型：
--
作者：
Wu H;Deng Y;Zhao M;Zhang J;Zheng M;Chen G;Li L;He Z;Lu Q
Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Blimp-1). In addition, cytokines, including IL-21, have been found to be important for Tfh cell development. Moreover, several epigenetic modifications have also been reported to be involved in the determination of Tfh cell fate. The regulatory network is complicated, and the number of novel molecules demonstrated to control the fate of Tfh cells is increasing. Therefore, this review aims to summarize the current knowledge regarding the molecular regulation of Tfh cell development and differentiation at the protein level and at the epigenetic level to elucidate Tfh cell biology and provide potential targets for clinical interventions in the future.
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影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
DOI：
10.1073/pnas.1205834109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Bollig, Nadine;Bruestle, Anne;Lohoff, Michael
通讯作者：
Lohoff, Michael
影响因子：
5.4
作者：
Arnold, Carrie N.;Campbell, Daniel J.;Butcher, Eugene C.
通讯作者：
Butcher, Eugene C.
影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
7.3
作者：
Andris F;Denanglaire S;Anciaux M;Hercor M;Hussein H;Leo O
通讯作者：
Leo O