Brain functional connectivity during storage based on resting state functional magnetic resonance imaging with synchronous urodynamic testing in healthy volunteers
Brain functional connectivity during storage based on resting state functional magnetic resonance imaging with synchronous urodynamic testing in healthy volunteers
复制标题
基于健康志愿者静息态功能磁共振成像和同步尿动力学测试的存储期间的大脑功能连接
DOI：
10.1007/s11682-020-00362-y
复制
发表时间：
2020-07
影响因子：
3.2
通讯作者：
Gao Yi
中科院分区：
文献类型：
--
作者：
Zhao Lingna;Liao Limin;Gao Yi
该研究的目的是利用静息态功能磁共振成像（rs-fMRI）并同时对健康志愿者进行尿动力学测试，从功能连接的角度阐明空间不同的大脑区域与膀胱充盈之间的相关性。使用 3 T 磁共振系统通过 rs-fMRI 报告膀胱充满和空的大脑区域。然后，我们通过使用大脑成像软件（DPABI和SPM8）计算低频波动（ALFF）值的幅度来确定膀胱充盈期间激活的大脑区域，并根据激活分析经验得出六个感兴趣区域（ROI），将其用作与大脑其余部分进行静息态功能连接（rs-FC）分析的种子，以检查两种条件下的差异。采用配对t检验进行统计分析，统计显着性定义为aP<0.01。招募了 22 名年龄在 35-64 岁之间的健康志愿者（11 名男性和 11 名女性）。对 22 名健康志愿者的 rs-fMRI 扫描进行了分析。运动校正后，两名受试者被排除。在其中 20 名受试者身上获得了有意义的数据。与空膀胱相比，功能连接增强主要见于右侧眶额下皮质和双侧距状回、左侧舌回、左侧梭状回、左侧枕上回、右侧岛叶、右侧颞下回、顶上叶、左侧岛叶、右侧舌回、右侧梭状回、左侧海马旁回、右侧颞下回、上回顶叶、左侧距状回、双侧舌回、前额皮质（包括额中回和额上回）、右侧颞中回、双侧后扣带皮层和右侧楔前叶。功能连接减少主要位于右侧眶额下皮质、前额叶皮质，包括额上回、眶额皮质和前扣带皮层，左侧眶额下皮质、右侧岛叶、枕中回、角回、额下回、右侧岛叶、颞中回、顶下叶、枕中回、辅助运动区、额上回、左侧岛叶、双侧后扣带皮层、双侧楔前叶、枕中回、右侧颞叶中叶。健康志愿者的满膀胱和空膀胱之间的大脑功能连接发生了显着变化，这表明参与存储的中枢神经过程需要具有集成控制的大脑区域。这些发现为医生考虑尿液储存中的大脑反应提供了强有力的证据，并提供了一些规范数据。
The aim of the study was to elucidate the correlation between spatially distinct brain areas with a full bladder from the perspective of functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) with simultaneous urodynamic testing in healthy volunteers. The brain regions with full and empty bladders were reported via rs-fMRI using a 3 T magnetic resonance system. Then, we identified brain regions that are activated during bladder filling by calculating the amplitude of low-frequency fluctuation (ALFF) values using brain imaging software (DPABI and SPM8) and empirically derived six regions of interest (ROI) from analysis of activation were used as seeds for resting-state functional connectivity (rs-FC) analysis with the rest of the brain to examine differences in the two conditions. Statistical analysis was performed with a paired t-test and statistical significance was defined as aP< 0.01. Twenty-two healthy volunteers (11 men and 11 women) 35–64 years of age were enrolled. The rs-fMRI scans of 22 healthy volunteers were analyzed. After motion correction, two subjects were excluded. Meaningful data were obtained on 20 of these subjects. Compared with an empty bladder, functional connection enhancement was noted mainly in the right inferior orbitofrontal cortex and bilateral calcarine gyrus, the left lingual gyrus, left fusiform gyrus, left superior occipital gyrus, right insula, right inferior temporal gyrus, superior parietal lobe, left insula, right lingual gyrus, right fusiform gyrus, left parahippocampal gyrus, right inferior temporal gyrus, superior parietal lobe, left calcarine gyrus, bilateral lingual gyrus, prefrontal cortex, including the middle frontal gyrus and superior frontal gyrus, the right middle temporal gyrus, bilateral posterior cingulate cortex, and right precuneus. The decrease in functional connection was mainly located in the right inferior orbitofrontal cortex, prefrontal cortex, including the superior frontal gyrus, orbitofrontal cortex, and anterior cingulate cortex, the left inferior orbitofrontal cortex, right insula, middle occipital gyrus, angular gyrus, inferior frontal gyrus, right insula, middle temporal gyrus, inferior parietal lobe, middle occipital gyrus, supplementary motor area, superior frontal gyrus, left insula, bilateral posterior cingulate cortex, bilateral precuneus, middle occipital gyrus, and right middle temporal lobe. There were significant changes in the functional connectivity of the brain between full and empty bladders in healthy volunteers, which suggests that the central neural processes involved in storage needs brain areas with integrated control. These findings are strong evidence for physicians to consider brain responses in urine storage and offer the provision of some normative data.
登录
查看更多内容
影响因子：
5.1
作者：
Zare A;Jahanshahi A;Rahnama'i MS;Schipper S;van Koeveringe GA
通讯作者：
van Koeveringe GA
影响因子：
2.6
作者：
Krhut, Jan;Holy, Petr;Zvara, Peter
通讯作者：
Zvara, Peter
影响因子：
5.7
作者：
Seseke, S.;Baudewig, J.;Dechent, P.
通讯作者：
Dechent, P.
影响因子：
2.5
作者：
Bharat, R;Kavia, C;Fowler, CJ
通讯作者：
Fowler, CJ
影响因子：
14.5
作者：
Franzmeier, Nicolai;Rubinski, Anna;Ewers, Michael
通讯作者：
Ewers, Michael