Cellular and molecular actions of Methylene Blue in the nervous system.
Cellular and molecular actions of Methylene Blue in the nervous system.
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DOI：
10.1002/med.20177
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发表时间：
2011-01
影响因子：
13.3
通讯作者：
Petroianu, George A.
中科院分区：
文献类型：
--
作者：
Oz, Murat;Lorke, Dietrich E.;Hasan, Mohammed;Petroianu, George A.
亚甲基蓝（MB）在世纪由埃利希引入生物学后，已在医学和生物学的各个领域中得到应用。目前，MB是高铁血红蛋白血症的一线治疗，常用于治疗异环磷酰胺诱导的脑病，并在外科手术中常规用作诊断工具。此外，最近的研究表明，MB对阿尔茨海默病和记忆改善具有有益作用。虽然cGMP途径的调节被认为是MB最重要的作用，介导其药理学作用，但最近的研究表明它具有多个细胞和分子靶点。在大多数情况下，MB的生物效应和临床应用取决于其独特的理化性质，包括其平面结构、氧化还原化学、离子电荷和光谱特征。在这篇评论文章中，这些物理化学特征和MB对多个细胞和分子靶点的作用进行了讨论，就其与神经系统的相关性。
Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide-induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article, these physicochemical features and the actions of MB on multiple cellular and molecular targets are discussed with regard to their relevance to the nervous system.
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影响因子：
3.6
作者：
Alici-Evcimen, Yesne;Breitbart, William S.
通讯作者：
Breitbart, William S.
DOI：
10.1007/bf01686508
发表时间：
1971-01-01
期刊：
Histochemical Journal
影响因子：
--
作者：
BARBOSA P;PETERS T M
通讯作者：
PETERS T M
DOI：
10.2165/00139709-200322010-00003
发表时间：
2003-01-01
期刊：
Toxicological Reviews
影响因子：
--
作者：
Bradberry, Sally M.
通讯作者：
Bradberry, Sally M.
影响因子：
1.6
作者：
Bardakci, H.;Kaplan, S.;Cobanoglu, A.
通讯作者：
Cobanoglu, A.
DOI：
10.1111/j.1365-2885.1984.tb00904.x
发表时间：
1984-01-01
影响因子：
1.3
作者：
BURROWS, GE
通讯作者：
BURROWS, GE