The oral bacterial microbiota facilitates the stratification for ulcerative colitis patients with oral ulcers.
The oral bacterial microbiota facilitates the stratification for ulcerative colitis patients with oral ulcers.
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DOI：
10.1186/s12941-023-00646-3
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发表时间：
2023-11-09
影响因子：
5.7
通讯作者：
Liu, Yu-Lan
中科院分区：
文献类型：
--
作者：
Xu, Jun;Zhang, Yu;Fang, Xiao-Hui;Liu, Yun;Huang, Yi-Bo;Ke, Zi-Liang;Wang, Yang;Zhang, Yi-Fan;Zhang, Yang;Zhou, Jian-Hua;Su, Hui-Ting;Chen, Ning;Liu, Yu-Lan
临床上，很大一部分炎症性肠病（IBD）患者并发口腔病变。虽然先前的研究证明了IBD患者的口腔微生物生态失调，但这些IBD患者合并口腔溃疡的胃肠道（GI）中的细菌群落尚未被描述。在这项研究中，我们招募了四组受试者，包括健康对照组（CON），口腔溃疡患者（UC），溃疡性结肠炎患者（UC_EN）和无（UC）口腔溃疡。收集来自三个GI小生境的生物样品，包括唾液、口腔和粪便样品，用于16 S rRNA V3-V4区域测序。对22例UC和10例UC_（10）经5-氨基水杨酸（5-阿萨）常规治疗的患者进行了6个月的随访;根据他们的治疗反应（内窥镜马约评分的降低），他们被进一步亚组为有反应和无反应的患者。我们发现合并口腔溃疡的UC患者治疗反应较弱，梭杆菌、奥里杆菌和弯曲杆菌可能与治疗反应有关。此外，唾液微生物组可能是5-阿萨常规治疗而不是口腔或粪便治疗反应的指标。粪便菌群对宿主的免疫指标有很强的影响，而口腔细菌菌群有助于溃疡性结肠炎患者口腔溃疡的分层。此外，口腔菌群在反映UC患者的治疗反应方面具有潜在作用。三种口腔细菌属（梭杆菌属、奥里杆菌属和弯曲杆菌属）可能与缺乏治疗反应的口腔溃疡患者有关，监测口腔微生物群可能对评估UC患者的治疗反应有意义。在线版本包含补充材料，可通过10.1186/s12941-023-00646-3获得。
Clinically, a large part of inflammatory bowel disease (IBD) patients is complicated by oral lesions. Although previous studies proved oral microbial dysbiosis in IBD patients, the bacterial community in the gastrointestinal (GI) tract of those IBD patients combined with oral ulcers has not been profiled yet. In this study, we enrolled four groups of subjects, including healthy controls (CON), oral ulcer patients (OU), and ulcerative colitis patients with (UC_OU) and without (UC) oral ulcers. Bio-samples from three GI niches containing salivary, buccal, and fecal samples, were collected for 16S rRNA V3-V4 region sequencing. Bacterial abundance and related bio-functions were compared, and data showed that the fecal microbiota was more potent than salivary and buccal microbes in shaping the host immune system. ~ 22 UC and 10 UC_OU 5-aminosalicylate (5-ASA) routine treated patients were followed-up for six months; according to their treatment response (a decrease in the endoscopic Mayo score), they were further sub-grouped as responding and non-responding patients. We found those UC patients complicated with oral ulcers presented weaker treatment response, and three oral bacterial genera, i.e., Fusobacterium, Oribacterium, and Campylobacter, might be connected with treatment responding. Additionally, the salivary microbiome could be an indicator of treatment responding in 5-ASA routine treatment rather than buccal or fecal ones. The fecal microbiota had a strong effect on the host’s immune indices, while the oral bacterial microbiota could help stratification for ulcerative colitis patients with oral ulcers. Additionally, the oral microbiota had the potential role in reflecting the treatment response of UC patients. Three oral bacteria genera (Fusobacterium, Oribacterium, and Campylobacter) might be involved in UC patients with oral ulcers lacking treatment responses, and monitoring oral microbiota may be meaningful in assessing the therapeutic response in UC patients. The online version contains supplementary material available at 10.1186/s12941-023-00646-3.
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DOI：
10.1038/nrmicro3552
发表时间：
2016-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Donaldson GP;Lee SM;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
14.9
作者：
Kanehisa M;Furumichi M;Sato Y;Ishiguro-Watanabe M;Tanabe M
通讯作者：
Tanabe M
DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Suda W;Luo C;Kawaguchi T;Motoo I;Narushima S;Kiguchi Y;Yasuma K;Watanabe E;Tanoue T;Thaiss CA;Sato M;Toyooka K;Said HS;Yamagami H;Rice SA;Gevers D;Johnson RC;Segre JA;Chen K;Kolls JK;Elinav E;Morita H;Xavier RJ;Hattori M;Honda K
通讯作者：
Honda K
影响因子：
12.2
作者：
Fang Z;Pan T;Li L;Wang H;Zhu J;Zhang H;Zhao J;Chen W;Lu W
通讯作者：
Lu W
影响因子：
6.4
作者：
Engevik MA;Danhof HA;Ruan W;Engevik AC;Chang-Graham AL;Engevik KA;Shi Z;Zhao Y;Brand CK;Krystofiak ES;Venable S;Liu X;Hirschi KD;Hyser JM;Spinler JK;Britton RA;Versalovic J
通讯作者：
Versalovic J