Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma.
Integrative analysis of competing endogenous RNA network focusing on long noncoding RNA associated with progression of cutaneous melanoma.
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竞争性内源性 RNA 网络的综合分析，重点关注与皮肤黑色素瘤进展相关的长非编码 RNA
DOI：
10.1002/cam4.1315
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发表时间：
2018-04
期刊：
影响因子：
4
通讯作者：
Liang G
中科院分区：
文献类型：
--
作者：
Xu S;Sui J;Yang S;Liu Y;Wang Y;Liang G
皮肤黑色素瘤（CM）是皮肤癌中恶性程度最高的肿瘤，其发病迅速，死亡率高。长链非编码RNA（longnoncodingRNAs，lncRNAs）在CM的发生和转移过程中发挥重要作用，并与microRNAs（miRNAs）和mRNAs相互作用，有望成为检测CM进展过程中病情恶化、改善预后的有效生物标志物。充分应用生物信息学分析来预测重要的lncRNA以及相关的miRNA和mRNA，最终构建了竞争性内源RNA（ceRNA）网络来解释CM进展中的RNA表达模式。进一步的统计分析强调了这些关键基因的重要性，这些关键基因与来自ceRNA网络的一个或几个临床特征在统计学上显著相关。结果表明，lncRNAs MGC12926和LINC00937与CM患者的预后密切相关。
Cutaneous melanoma (CM) is the most malignant tumor of skin cancers because of its rapid development and high mortality rate. Long noncoding RNAs (lncRNAs), which play essential roles in the tumorigenesis and metastasis of CM and interplay with microRNAs (miRNAs) and mRNAs, are hopefully considered to be efficient biomarkers to detect deterioration during the progression of CM to improve the prognosis. Bioinformatics analysis was fully applied to predict the vital lncRNAs and the associated miRNAs and mRNAs, which eventually constructed the competing endogenous RNA (ceRNA) network to explain the RNA expression patterns in the progression of CM. Further statistical analysis emphasized the importance of these key genes, which were statistically significantly related to one or few clinical features from the ceRNA network. The results showed the lncRNAs MGC12926 and LINC00937 were verified to be strongly connected with the prognosis of CM patients.
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影响因子：
5.2
作者：
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通讯作者：
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影响因子：
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作者：
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竞争性内源性 RNA 网络与胃癌
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影响因子：
13.6
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Perera RJ