SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19.
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DOI：
10.1016/j.celrep.2022.111573
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发表时间：
2022-11-01
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications in some patients. However, it is still under debate whether SARS-CoV-2 directly infects the brain or whether CNS sequelae result from systemic inflammatory responses triggered in the periphery. By using high-resolution microscopy, we investigated whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated by aging in a non-human primate model of COVID-19. Seven days after infection, SARS-CoV-2 was detected in the olfactory cortex and interconnected regions and was accompanied by robust neuroinflammation and neuronal damage exacerbated in aged, diabetic animals. Our study provides an initial framework for identifying the molecular and cellular mechanisms underlying SARS-CoV-2 neurological complications, which will be essential to reducing both the short- and long-term burden of COVID-19. In macaques, SARS-CoV-2 is found in olfactory brain areas at 7 days post infection Neurons are initially the primary target of SARS-CoV-2 productive infection Neurocovid is accompanied by robust neuroinflammation and vascular disruption SARS-CoV-2 brain pathology is worsened by aging and diabetes in infected monkeys Beckman et al. show that SARS-CoV-2 proteins are found in olfactory areas of the brains of rhesus macaques at 7 days post infection. In addition to direct neuronal infection, extensive neuroinflammation and vascular disruptions are observed, and these effects are exacerbated in aged, diabetic animals.
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影响因子：
4.8
作者：
Mainali S;Darsie ME
通讯作者：
Darsie ME
DOI：
10.1002/alz.12318
发表时间：
2021-06
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Beckman D;Chakrabarty P;Ott S;Dao A;Zhou E;Janssen WG;Donis-Cox K;Muller S;Kordower JH;Morrison JH
通讯作者：
Morrison JH
影响因子：
16.6
作者：
Rutkai I;Mayer MG;Hellmers LM;Ning B;Huang Z;Monjure CJ;Coyne C;Silvestri R;Golden N;Hensley K;Chandler K;Lehmicke G;Bix GJ;Maness NJ;Russell-Lodrigue K;Hu TY;Roy CJ;Blair RV;Bohm R;Doyle-Meyers LA;Rappaport J;Fischer T
通讯作者：
Fischer T
DOI：
10.1016/s1474-4422(20)30371-9
发表时间：
2020-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Frank S
通讯作者：
Frank S
影响因子：
5.8
作者：
Fodoulian L;Tuberosa J;Rossier D;Boillat M;Kan C;Pauli V;Egervari K;Lobrinus JA;Landis BN;Carleton A;Rodriguez I
通讯作者：
Rodriguez I