Air pollution exposure during pregnancy: maternal asthma and neonatal respiratory outcomes.
Air pollution exposure during pregnancy: maternal asthma and neonatal respiratory outcomes.
复制标题
DOI：
10.1016/j.annepidem.2018.06.003
复制
发表时间：
2018-09
影响因子：
5.6
通讯作者：
Mendola P
中科院分区：
文献类型：
--
作者：
Seeni I;Ha S;Nobles C;Liu D;Sherman S;Mendola P
母亲哮喘会增加新生儿的不良呼吸结局，污染可能会进一步增加风险。空气质量与新生儿呼吸健康的关系尚未得到研究。2002年至2008年，来自安全分娩联盟的223,375名独生子女的医疗记录被确认为新生儿短暂性呼吸急促(TTN)、窒息和呼吸窘迫综合征(RDS)。社区多尺度空气质量模型估计的污染物暴露。多污染物泊松回归模型计算了平均暴露四分位数范围内增加的结果的调整后的相对风险。母亲哮喘和早产被评估为效果修饰物。妊娠期和妊娠三个月期间的颗粒物(PM)暴露小于或等于10微米(9-10%)，以及整个孕期暴露在PM小于或等于2.5微米(PM2.5；17%)和一氧化碳(CO；10%)的情况下，TTN的风险增加。在妊娠1个月(48%)和整个妊娠期间暴露于PM2.5(48%)，在妊娠2个月和整个妊娠期间暴露于一氧化碳(28%-32%)，以及持续暴露于臭氧(34%-73%)后，窒息的风险增加。RDS的风险与所有妊娠期间氮氧化物(33%-42%)和臭氧(9%-21%)浓度的增加有关。观察到了与几种污染物，特别是二氧化硫之间的反向关联。未观察到与母亲哮喘的相互作用。对足月出生的限制也产生了类似的结果。几种污染物似乎增加了新生儿呼吸结局的风险。
Maternal asthma increases adverse neonatal respiratory outcomes, and pollution may further increase risk. Air quality in relation to neonatal respiratory health has not been studied. Transient tachypnea of the newborn (TTN), asphyxia, and respiratory distress syndrome (RDS) were identified using medical records among 223,375 singletons from the Consortium on Safe Labor (2002–2008). Community Multiscale Air Quality models estimated pollutant exposures. Multipollutant Poisson regression models calculated adjusted relative risks of outcomes for interquartile range increases in average exposure. Maternal asthma and preterm delivery were evaluated as effect modifiers. TTN risk increased after particulate matter (PM) less than or equal to 10-micron exposure during preconception and trimester one (9–10%), and whole-pregnancy exposure to PM less than or equal to 2.5 microns (PM2.5; 17%) and carbon monoxide (CO; 10%). Asphyxia risk increased after exposure to PM2.5 in trimester one (48%) and whole pregnancy (84%), CO in trimester two and whole pregnancy (28–32%), and consistently for ozone (34%–73%). RDS risk was associated with increased concentrations of nitrogen oxides (33%–42%) and ozone (9%–21%) during all pregnancy windows. Inverse associations were observed with several pollutants, particularly sulfur dioxide. No interaction with maternal asthma was observed. Restriction to term births yielded similar results. Several pollutants appear to increase neonatal respiratory outcome risks.
登录
查看更多内容
影响因子：
8.3
作者：
Ha S;Zhu Y;Liu D;Sherman S;Mendola P
通讯作者：
Mendola P
影响因子：
8.3
作者：
Robledo CA;Mendola P;Yeung E;Männistö T;Sundaram R;Liu D;Ying Q;Sherman S;Grantz KL
通讯作者：
Grantz KL
影响因子：
24.3
作者：
Latzin, P.;Roeoesli, M.;Frey, U.
通讯作者：
Frey, U.
影响因子：
8.3
作者：
Mendola P;Wallace M;Liu D;Robledo C;Mӓnnistӧ T;Grantz KL
通讯作者：
Grantz KL
影响因子：
2
作者：
Gallacher, David J.;Hart, Kylie;Kotecha, Sailesh
通讯作者：
Kotecha, Sailesh