Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus.
Preconception and early pregnancy air pollution exposures and risk of gestational diabetes mellitus.
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DOI：
10.1016/j.envres.2014.12.020
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发表时间：
2015-03
影响因子：
8.3
通讯作者：
Grantz KL
中科院分区：
文献类型：
--
作者：
Robledo CA;Mendola P;Yeung E;Männistö T;Sundaram R;Liu D;Ying Q;Sherman S;Grantz KL
空气污染与妊娠期糖尿病（GDM）有关，但没有研究评估孕前和妊娠早期空气污染暴露对GDM风险的影响。电子医疗记录提供了219,952例单胎分娩的数据，这些产妇有（n=11,334）和没有GDM （n=208,618）。基于改进的社区多尺度空气质量模型，对分娩医院转诊地区的3个月孕前窗口、孕早期和妊娠1-24周的产妇平均暴露于<2.5微米（PM2.5）和PM2.5成分、PM <10微米（PM10）、氮氧化物（NOx）、一氧化碳、二氧化硫（SO2）和臭氧（O3）进行了估计。具有稳健标准误差的二元回归模型估计了污染物浓度每四分位数范围（IQR）增加的GDM的相对风险（RR），调整了研究地点、母亲年龄和种族/民族。孕前母体暴露于NOX （RR=1.09, 95% CI: 1.04, 1.13）和SO2 （RR=1.05, 1.01, 1.09）与随后发生GDM的风险增加相关，并且妊娠早期暴露的风险估计值仍然升高。孕前O3与随后发生GDM的风险较低相关（RR=0.93, 0.90, 0.96），但妊娠后期风险增加。孕妇在孕前和怀孕最初几周暴露于NOX和SO2与GDM风险增加有关。O3似乎与妊娠中期暴露增加GDM风险有关，但与早期时间窗无关。这些常见的暴露值得进一步调查。
Air pollution has been linked to gestational diabetes mellitus (GDM) but no studies have evaluated impact of preconception and early pregnancy air pollution exposures on GDM risk. Electronic medical records provided data on 219,952 singleton deliveries to mothers with (n=11,334) and without GDM (n=208,618). Average maternal exposures to particulate matter (PM) <2.5 microns (PM2.5) and PM2.5 constituents, PM <10 microns (PM10), nitrogen oxides (NOx), carbon monoxide, sulfur dioxide (SO2) and ozone (O3) were estimated for the 3-month preconception window, first trimester, and gestational weeks 1-24 based on modified Community Multiscale Air Quality models for delivery hospital referral regions. Binary regression models with robust standard errors estimated relative risks (RR) for GDM per interquartile range (IQR) increase in pollutant concentrations adjusted for study site, maternal age and race/ethnicity. Preconception maternal exposure to NOX (RR=1.09, 95% CI: 1.04, 1.13) and SO2 (RR=1.05, 1.01, 1.09) were associated with increased risk of subsequent GDM and risk estimates remained elevated for first trimester exposure. Preconception O3 was associated with lower risk of subsequent GDM (RR=0.93, 0.90, 0.96) but risks increased later in pregnancy. Maternal exposures to NOX and SO2 preconception and during the first few weeks of pregnancy were associated with increased GDM risk. O3 appeared to increase GDM risk in association with mid-pregnancy exposure but not in earlier time windows. These common exposures merit further investigation.
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影响因子：
16.2
作者：
Andersen ZJ;Raaschou-Nielsen O;Ketzel M;Jensen SS;Hvidberg M;Loft S;Tjønneland A;Overvad K;Sørensen M
通讯作者：
Sørensen M
DOI：
10.1164/ajrccm.153.5.8630615
发表时间：
1996-05-01
影响因子：
24.7
作者：
Bennett, WD;Zeman, KL;Kim, C
通讯作者：
Kim, C
影响因子：
2.8
作者：
Basile, Jan N.;Bloch, Michael J.
通讯作者：
Bloch, Michael J.
影响因子：
7.7
作者：
Rajagopalan S;Brook RD
通讯作者：
Brook RD
影响因子：
16.2
作者：
Khafaie MA;Salvi SS;Ojha A;Khafaie B;Gore SS;Yajnik CS
通讯作者：
Yajnik CS