KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.
KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.
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DOI：
10.1007/s00251-014-0794-1
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发表时间：
2014-11
期刊：
影响因子：
3.2
通讯作者：
Norman, Paul J.
中科院分区：
文献类型：
--
作者：
Nemat-Gorgani, Neda;Edinur, Hisham A.;Hollenbach, Jill A.;Traherne, James A.;Dunn, Paul P. J.;Chambers, Geoffrey K.;Parham, Peter;Norman, Paul J.
人类白细胞抗原I类分子和杀伤细胞免疫球蛋白样受体(KIR)形成了一个多样化的配体和受体系统，以提高个人和群体的存活率的方式使人类免疫系统个体化。东亚和东南亚移民在大洋洲的人类定居始于约3500年前。随后，祖先MāOri在7500年前到达新西兰。为了研究这一病史如何影响KIR和人类白细胞抗原的多样性及其功能相互作用，我们以高分辨率定义了49名MāORI和34名波利尼西亚人13个表达的KIR基因的等位基因和单倍型多样性。我们定义了80个KIR变异体，其中包括4个‘新’等位基因；还有35个着丝粒和22个端粒KIR区单倍型，它们结合在一起得到了50个全长KIR单倍型。两个新的和不同的KIR变异形成了端粒KIR单倍型的一部分，该单倍型似乎来自巴布亚新几内亚，可能是由前往波利尼西亚的亚洲移民获得的。Māori和波利尼西亚KIR非常相似，但与非洲、欧洲、日本和美洲印第安人的KIR有显著差异。M、ā、Ori和波利尼西亚人具有较高的KIR单倍型多样性，相应的同种异型多样性在整个KIR基因座中保持不变。在种群中，每个个体都有独特的HLAI类和KIR组合。MHLAORI和波利尼西亚人的特征是缺乏ā-B同种异型。弥补这一缺陷的是KIR识别的高频率(>；50%)的人类白细胞抗原-A同种异型。这些人类白细胞抗原-A同种异型可能是现代人在更早的时候从古代人那里获得的。
HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started ~3,500 years ago. Subsequently, New Zealand was reached ~750 years ago by ancestral Māori. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 Māori and 34 Polynesians. Eighty KIR variants, including four ‘new’ alleles, were defined; as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give >50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. Māori and Polynesian KIR are very similar, but differ significantly from African, European, Japanese and Amerindian KIR. Māori and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population each individual has a unique combination of HLA class I and KIR. Characterizing Māori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (>50%) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time.
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影响因子：
2.7
作者：
Hou, LiHua;Chen, Minghua;Jiang, Bo;Kariyawasam, Kanthi;Ng, Jennifer;Hurley, Carolyn Katovich
通讯作者：
Hurley, Carolyn Katovich
影响因子：
14.9
作者：
Gonzalez-Galarza FF;Christmas S;Middleton D;Jones AR
通讯作者：
Jones AR
DOI：
10.1073/pnas.0906051106
发表时间：
2009-11-03
影响因子：
11.1
作者：
Gendzekhadze, Ketevan;Norman, Paul J.;Parham, Peter
通讯作者：
Parham, Peter
影响因子：
2.2
作者：
Hollenbach JA;Augusto DG;Alaez C;Bubnova L;Fae I;Fischer G;Gonzalez-Galarza FF;Gorodezky C;Karabon L;Kusnierczyk P;Noble J;Rickards O;Roberts C;Schaffer M;Shi L;Tavoularis S;Trachtenberg E;Yao Y;Middleton D
通讯作者：
Middleton D
DOI：
10.1084/jem.181.3.1133
发表时间：
1995-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gumperz JE;Litwin V;Phillips JH;Lanier LL;Parham P
通讯作者：
Parham P