Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience.
Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience.
复制标题
薄子宫内膜患者的累积活产率：真实世界的单中心经验
DOI：
10.3389/fendo.2020.00469
复制
发表时间：
2020
影响因子：
5.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Bu Z;Hu L;Yang X;Sun Y
背景资料：研究表明，IVF/ICSI期间子宫内膜厚度较薄（EMT < 7或8 mm）的患者往往会出现不良妊娠结局，这给患者和医生在面临薄EMT时造成了很大的焦虑。方法：从2015年1月至2018年12月，纳入了在第一个GnRH激动剂IVF/ICSI周期期间hCG给药当天EMT < 7 mm的患者。根据宫腔镜检查结果将患者分为完全正常（A组）、正常伴特定异常（B组）和转移前粘连（C组）。结果：在纳入的245例患者中，约60%的薄EMT病例是宫内手术的结果。CLBR为35.45%（67/189）。在CLBR方面，无论取卵数如何，这三个子宫条件组之间均存在显著差异（卵母细胞≤5个时，28.57 vs. 10.00 vs. 4.76%，P = 0.12;卵母细胞>5个时，61.36 vs. 44.67 vs. 23.63%，P = 0.00）。在二元逻辑回归分析中，年龄（OR = 0.09，P = 0.03）、可用胚胎数（OR = 1.71，P = 0.00）和子宫状况（A组OR = 6.77，P = 0.00; B组OR = 2.55，P = 0.04;参考= C组）与CLBR显著相关。然而，EMT和子宫内膜类型对CLBR没有影响。结论：宫内手术是子宫内膜异位症薄的主要原因。与转移前有粘连的患者相比，宫腔和子宫内膜正常的薄EMT患者的CLBR明显更好。
Background: Studies have shown that patients with a thin endometrial thickness (EMT < 7 or 8 mm) during IVF/ICSI tend to have adverse pregnancy outcomes, and this has caused much anxiety to both patients and physicians when confronted with a thin EMT. Method: From January 2015 to December 2018, patients with a thin EMT < 7 mm on the day of hCG administration during their first GnRH agonist IVF/ICSI cycle were included. According to the hysteroscopy results, patients were classified into totally normal (Group A), normal with a specific abnormality (Group B), and adhesion before transfer (Group C). Result: For the 245 patients included, approximately 60% of the thin EMT cases were the result of an intrauterine operation. CLBR was 35.45% (67/189) in this group of patients. In regard to CLBR, there were significant differences among these three uterus condition groups irrespective of the number of oocytes retrieved (28.57 vs. 10.00 vs. 4.76%, P = 0.12 in oocyte ≤5; 61.36 vs. 44.67 vs. 23.63%, P = 0.00 in oocyte >5). In binary logistic regression analysis, age (OR = 0.09, P = 0.03), number of embryos available (OR = 1.71, P = 0.00), and uterine condition (OR = 6.77, P = 0.00 for group A; OR = 2.55, P = 0.04 for group B; Reference = group C), were significantly associated with CLBR. However, EMT and endometrial pattern had no impact on CLBR. Conclusion: An intrauterine operation was the main reason for a thin EMT. Thin EMT patients with a normal uterine cavity and endometrium had a significantly better CLBR compared with those with adhesions before transfer.
登录
查看更多内容
DOI：
10.1093/humrep/dey281
发表时间：
2018-10-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Liu KE;Hartman M;Hartman A;Luo ZC;Mahutte N
通讯作者：
Mahutte N
影响因子：
6.1
作者：
Sunkara, Sesh Kamal;Khairy, Mohammed;Coomarasamy, Arri
通讯作者：
Coomarasamy, Arri
影响因子：
2.9
作者：
Song, Jianyuan;Sun, Xuejiao;Qian, Kun
通讯作者：
Qian, Kun
DOI：
10.1186/s12958-017-0233-x
发表时间：
2017-03-04
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Wu D;Kimura F;Zheng L;Ishida M;Niwa Y;Hirata K;Takebayashi A;Takashima A;Takahashi K;Kushima R;Zhang G;Murakami T
通讯作者：
Murakami T
影响因子：
2.6
作者：
Moffat, Rebecca;Beutler, Sjanneke;De Geyter, Christian
通讯作者：
De Geyter, Christian