Neural Correlates of Working Memory Maintenance in Advanced Aging: Evidence From fMRI.
Neural Correlates of Working Memory Maintenance in Advanced Aging: Evidence From fMRI.
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DOI：
10.3389/fnagi.2018.00358
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发表时间：
2018
影响因子：
4.8
通讯作者：
Sekiyama K
中科院分区：
文献类型：
--
作者：
Suzuki M;Kawagoe T;Nishiguchi S;Abe N;Otsuka Y;Nakai R;Asano K;Yamada M;Yoshikawa S;Sekiyama K
工作记忆（WM）相关的大脑活动被认为是由老化调制;特别是，老年人表现出更大的活动比年轻人。然而，目前还不清楚老年人的活动增加是否也在晚期衰老中观察到。本功能磁共振成像（fMRI）的研究旨在阐明在先进的老龄化WM的神经相关性。此外，我们着手调查的情况下，成年人的先进的年龄确实表现出与年龄相关的增加WM相关的活动，这种过度招聘的功能意义可能是什么。两组老年人-“61-70岁”（n = 17）和“老-老”（77-82岁，n = 16）-进行扫描，同时执行视觉WM任务（n-back任务：0-back和1-back）。两个年龄组共有的WM效应（1-back > 0-back）在几个区域被确定，包括双侧背外侧前额叶皮层（DLPFC），顶叶下皮层和小脑。在右侧尾侧DLPFC中，老年-老年组的WM效应大于老年-老年组。当我们在两个年龄组之间进行单独的分析时，这些结果得到了复制，这两个年龄组具有相同的WM表现水平（10岁-老年组与老年-老年组的“高表现”子集）。有没有区域，WM的影响是更大的，在10岁-老年组比在老年-老年组。重要的是，过度募集WM效应的大小与WM性能在老-老组呈正相关，但不是在老-老组。目前的研究结果表明，皮质过度招聘发生在先进的老年，增加活动可能是一种补偿功能，在介导WM性能。
Working memory (WM)-related brain activity is known to be modulated by aging; particularly, older adults demonstrate greater activity than young adults. However, it is still unclear whether the activity increase in older adults is also observed in advanced aging. The present functional magnetic resonance imaging (fMRI) study was designed to clarify the neural correlates of WM in advanced aging. Further, we set out to investigate in the case that adults of advanced age do show age-related increase in WM-related activity, what the functional significance of this over-recruitment might be. Two groups of older adults – “young–old” (61–70 years, n = 17) and “old–old” (77–82 years, n = 16) – were scanned while performing a visual WM task (the n-back task: 0-back and 1-back). WM effects (1-back > 0-back) common to both age groups were identified in several regions, including the bilateral dorsolateral prefrontal cortex (DLPFC), the inferior parietal cortex, and the insula. Greater WM effects in the old–old than in the young–old group were identified in the right caudal DLPFC. These results were replicated when we performed a separate analysis between two age groups with the same level of WM performance (the young–old vs. a “high-performing” subset of the old–old group). There were no regions where WM effects were greater in the young–old group than in the old–old group. Importantly, the magnitude of the over-recruitment WM effects positively correlated with WM performance in the old–old group, but not in the young–old group. The present findings suggest that cortical over-recruitment occurs in advanced old age, and that increased activity may serve a compensatory function in mediating WM performance.
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影响因子：
4.2
作者：
Adnan A;Chen AJW;Novakovic-Agopian T;D'Esposito M;Turner GR
通讯作者：
Turner GR
影响因子：
14.5
作者：
Daselaar, SM;Veltman, DJ;Jonker, C
通讯作者：
Jonker, C
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
24.8
作者：
D'Esposito M;Postle BR
通讯作者：
Postle BR
衰老对成功项目和源存储器编码的神经相关性的影响。
DOI：
10.1037/0278-7393.34.4.791
发表时间：
2008-07
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
Dennis NA;Hayes SM;Prince SE;Madden DJ;Huettel SA;Cabeza R
通讯作者：
Cabeza R