Brain Changes Following Executive Control Training in Older Adults.
Brain Changes Following Executive Control Training in Older Adults.
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DOI：
10.1177/1545968317728580
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发表时间：
2017-10
影响因子：
4.2
通讯作者：
Turner GR
中科院分区：
文献类型：
--
作者：
Adnan A;Chen AJW;Novakovic-Agopian T;D'Esposito M;Turner GR
虽然老年人能够关注与目标相关的信息，但忽略无关或分散注意力的信息的能力随着年龄的增长而下降。这种选择性注意力的下降与与认知控制有关的大脑前部区域对感觉皮质中的大脑活动调节不力有关。在这里，我们调查了参加执行控制训练计划是否会改善健康老年人(N=24，年龄60-85岁)的选择性注意力和相关的脑功能变化。方法：受试者参加以目标为导向的注意自我调节(Goals)计划(N=11)或脑健康教育工作坊(N=13)作为主动控制条件。所有参与者都执行了一项工作记忆任务，要求在功能磁共振成像(FMRI)扫描期间注意或抑制基于目标相关性的视觉刺激。我们观察到目标干预组从训练前到训练后右侧额叶、顶叶和颞叶脑区活动增强的模式，这预示了后续记忆对目标相关刺激的选择性。老年人的执行控制训练改变了与注意力控制相关的大脑区域的功能活动，并选择性地预测行为结果。
While older adults are able to attend to goal-relevant information, the capacity to ignore irrelevant or distracting information declines with advancing age. This decline in selective attention has been associated with poor modulation of brain activity in sensory cortices by anterior brain regions implicated in cognitive control. Here we investigated whether participation in an executive control training program would result in improved selective attention and associated functional brain changes in a sample of healthy older adults (N=24, ages 60-85 years). Methods: Participants were enrolled in a goal-oriented attentional self-regulation (GOALS) program (N=11) or a brain health education workshop as an active control condition (N=13). All participants performed a working memory task requiring attention to or suppression of visual stimuli based on goal-relevance during functional MRI (fMRI) scanning. We observed a pattern of enhanced activity in right frontal, parietal and temporal brain regions from pre- to post-training in the GOALS intervention group, which predicted the selectivity of subsequent memory for goal-relevant stimuli. Executive control training in older adults alters functional activity in brain regions associated with attentional control, and selectively predicts behavioural outcome.
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影响因子：
14.5
作者：
Belleville, Sylvie;Clement, Francis;Gauthier, Serge
通讯作者：
Gauthier, Serge
DOI：
10.1017/s1355617707070178
发表时间：
2007-01-01
影响因子：
2.6
作者：
Levine, Brian;Stuss, Donald T.;Robertson, Ian H.
通讯作者：
Robertson, Ian H.
影响因子：
3.7
作者：
Kirchhoff, B. A.;Anderson, B. A.;Jacoby, L. L.
通讯作者：
Jacoby, L. L.
影响因子：
2.9
作者：
Brehmer Y;Westerberg H;Bäckman L
通讯作者：
Bäckman L
DOI：
10.1523/jneurosci.0627-12.2012
发表时间：
2012-10-31
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lee TG;D'Esposito M
通讯作者：
D'Esposito M