Oxidative stress and mitochondrial dysfunction in Alzheimer's disease.
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease.
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DOI：
10.1016/j.bbadis.2013.10.015
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发表时间：
2014-08
影响因子：
6.2
通讯作者：
Zhu, Xiongwei
中科院分区：
文献类型：
--
作者：
Wang, Xinglong;Wang, Wenzhang;Li, Li;Perry, George;Lee, Hyoung-gon;Zhu, Xiongwei
关键词：
阿尔茨海默病（AD）表现出全身广泛的氧化应激，可以在周围检测到，也与疾病中受影响的大脑脆弱区域有关。丰富的证据不仅显示了神经元大分子氧化损伤的全谱，而且揭示了氧化事件在疾病早期和病理形成之前的发生，支持氧化应激在AD中的重要作用。AD作为一种异常衰老疾病，其氧化损伤水平明显高于老年对照，提示有其他因素的参与。在结构和功能上受损的线粒体更擅长产生活性氧，但在ATP中却不那么擅长，这也是该疾病的早期和突出特征。由于线粒体也容易受到氧化应激的影响，因此线粒体功能障碍和氧化应激之间的相互作用可能导致了活性氧的启动和/或扩增，而活性氧对AD的发病至关重要。
Alzheimer’s disease (AD) exhibits extensive oxidative stress throughout the body, being detected peripherally as well as associated with the vulnerable regions of the brain affected in disease. Abundant evidence not only demonstrates the full spectrum of oxidative damage to neuronal macromolecules, but also reveals the occurrence of oxidative events early in the course of the disease and prior to the formation of the pathology, which support an important role of oxidative stress in AD. As a disease of abnormal aging, AD demonstrats oxidative damage at levels that significantly surpass that of elderly controls, which suggests the involvement of additional factor(s). Structurally and functionally damaged mitochondria, which are more proficient at producing reactive oxygen species but less so in ATP, are also an early and prominent feature of the disease. Since mitochondria are also vulnerable to oxidative stress, it is likely that a vicious downward spiral involving the interactions between mitochondrial dysfunction and oxidative stress contributes to the initiation and/or amplification of reactive oxygen species that is critical to the pathogenesis of AD.
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影响因子：
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