Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019.
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019.
复制标题
为什么OMICRON变体在很大程度上备用嗅觉功能？ 2019年冠状病毒病中厌食的发病机理的意义。
DOI：
10.1093/infdis/jiac113
复制
发表时间：
2022-10-17
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
The omicron variant of severe acute respiratory syndrome coronavirus 2 causes much less olfactory dysfunction than the previous variants. There are several potential mechanisms for how omicron may change tissue tropism and spare olfactory function. The new mutations make omicron more hydrophobic and alkaline than previous variants, which may reduce penetration of the mucus layer. Overall, the new mutations minimally change receptor binding affinity, but entry efficiency into host cells is reduced in cells expressing transmembrane serine protease 2 (TMPRSS2). Because the support cells in the olfactory epithelium abundantly express TMPRSS2, these main target cells in the olfactory epithelium may become infected less by the new omicron variant. The omicron variant of severe acute respiratory syndrome coronavirus 2 causes 3–4-fold less anosmia prevalence than previous variants. The molecular mechanisms responsible for reduced infection of olfactory cells may explain the sparing of olfactory function with the omicron variant.
登录
查看更多内容
影响因子：
4.5
作者：
Kim MK;Lee B;Choi YY;Um J;Lee KS;Sung HK;Kim Y;Park JS;Lee M;Jang HC;Bang JH;Chung KH;Jeon J
通讯作者：
Jeon J
DOI：
10.1016/s2468-2667(21)00055-4
发表时间：
2021-05
期刊：
The Lancet. Public health
影响因子：
--
作者：
Graham MS;Sudre CH;May A;Antonelli M;Murray B;Varsavsky T;Kläser K;Canas LS;Molteni E;Modat M;Drew DA;Nguyen LH;Polidori L;Selvachandran S;Hu C;Capdevila J;COVID-19 Genomics UK (COG-UK) Consortium;Hammers A;Chan AT;Wolf J;Spector TD;Steves CJ;Ourselin S
通讯作者：
Ourselin S
影响因子：
6.4
作者：
Hintschich CA;Niv MY;Hummel T
通讯作者：
Hummel T
影响因子：
64.5
作者：
Hoffmann M;Krüger N;Schulz S;Cossmann A;Rocha C;Kempf A;Nehlmeier I;Graichen L;Moldenhauer AS;Winkler MS;Lier M;Dopfer-Jablonka A;Jäck HM;Behrens GMN;Pöhlmann S
通讯作者：
Pöhlmann S
影响因子：
2.9
作者：
HARDING, JW;GETCHELL, TV;MARGOLIS, FL
通讯作者：
MARGOLIS, FL