Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population
Single Nucleotide Polymorphisms in the Interleukin-6 Gene Associated with Blood Pressure and Atherosclerosis in a Japanese General Population
复制标题
日本普通人群白细胞介素 6 基因单核苷酸多态性与血压和动脉粥样硬化相关
作者：
C. Tanaka;T. Mannami;K. Kamide;S. Takiuchi;Y. Kokubo;T. Katsuya;Y. Kawano;T. Miyata;T. Ogihara;H. Tomoike
It is known that increased plasma levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with atherosclerosis and myocardial infarction. The aim of this study was to reveal the contribution of the single nucleotide polymorphisms (SNPs) of the IL-6 gene on the blood pressure regulation and progression of atherosclerosis in a general Japanese population. In order to evaluate the potential implications of genetic variability of the IL-6 gene, we explored eight SNPs by direct sequencing for the entire coding region and the promoter region in the IL-6 gene and genotyped two SNPs, −636G>C in the promoter region and 1691C>G in intron 3, for a total of 2,421 Japanese subjects (1,162 men and 1,259 women). As a consequence, −636 G>C was significantly associated with systolic blood pressure (SBP) and carotid intima-media thickness (IMT) in women, and 1691C>G showed a relationship with SBP and carotid IMT in men after adjustment for all confounding factors. Although neither SNP had a significant correlation to the prevalence of hypertension, the haplotype frequency analysis indicated that the number of hypertensive men with a G allele at both −636 and 1691 was significantly greater than the number of nonhypertensive men with this combination. Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese.
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影响因子：
5.8
作者：
Ferrari, SL;Ahn-Luong, L;Greenspan, SL
通讯作者：
Greenspan, SL
DOI：
10.1097/00008571-200111000-00008
发表时间：
2001-11
期刊：
Pharmacogenetics
影响因子：
--
作者：
R. Zhai;Geoffrey Liu;Chaomin Yang;Chuonhong Huang;Chuanren Wu;D. Christiani
通讯作者：
R. Zhai;Geoffrey Liu;Chaomin Yang;Chuonhong Huang;Chuanren Wu;D. Christiani
影响因子：
39.3
作者：
Humphries, SE;Luong, LA;Miller, GJ
通讯作者：
Miller, GJ
影响因子：
37.8
作者：
Ridker, PM;Rifai, N;Hennekens, CH
通讯作者：
Hennekens, CH