Adrenoreceptor modulation of oromotor pathways in the rat medulla.
Adrenoreceptor modulation of oromotor pathways in the rat medulla.
复制标题
肾上腺素受体对大鼠髓质口腔运动通路的调节。
DOI：
10.1152/jn.00091.2014
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发表时间：
2014
影响因子：
2.5
通讯作者：
Travers,JosephB
中科院分区：
文献类型：
--
作者：
Nasse,JasonS;Travers,JosephB
摄食行为的调节涉及控制营养寻求和消费行为的多种生理和神经通路的整合。摄食的完成阶段包括通过脑干通路控制的舌头和下颌的刻板或重复运动。这些通路不仅包括脑神经感觉和运动核，用于处理与进食相关的传入信号并供应口咽肌，还包括网状神经元，用于协调摄食并将其与利用相同肌肉组织的其他行为协调。基于去大脑的研究，这个电路应该是敏感的饱腹感机制介导的A2去甲肾上腺素能神经元在孤束尾核（cNST），在饱腹感期间被有效地激活。由于饱腹感的第一个可观察阶段是抑制orbal运动，我们假设去甲肾上腺素（NE）将发挥抑制延髓网状结构中的前舌下神经元的作用。用逆行标记的舌下神经元膜片钳电生理和钙离子成像来验证这一假设，我们证明去甲肾上腺素可以通过α1和α2肾上腺素受体影响网状神经元的突触前和突触后特性。α1肾上腺素受体激动剂苯肾上腺素（PE）在TTX存在下激活内向电流，并增加抑制性和兴奋性微小突触后电流的频率。α2肾上腺素受体激动剂右美托咪定（DMT）通过突触前机制抑制cNST诱发的兴奋性电流以及自发和微小兴奋性电流。这些前舌下神经元肾上腺素受体调节的多样性可能反映了它们在协调摄食和呼吸舌功能的多功能回路中的作用。
Regulation of feeding behavior involves the integration of multiple physiological and neurological pathways that control both nutrient-seeking and consummatory behaviors. The consummatory phase of ingestion includes stereotyped oromotor movements of the tongue and jaw that are controlled through brain stem pathways. These pathways encompass not only cranial nerve sensory and motor nuclei for processing feeding-related afferent signals and supplying the oromotor musculature but also reticular neurons for orchestrating ingestion and coordinating it with other behaviors that utilize the same musculature. Based on decerebrate studies, this circuit should be sensitive to satiety mechanisms mediated centrally by A2 noradrenergic neurons in the caudal nucleus of the solitary tract (cNST) that are potently activated during satiety. Because the first observable phase of satiety is inhibition of oromotor movements, we hypothesized that norepinephrine (NE) would act to inhibit prehypoglossal neurons in the medullary reticular formation. Using patch-clamp electrophysiology of retrogradely labeled prehypoglossal neurons and calcium imaging to test this hypothesis, we demonstrate that norepinephrine can influence both pre- and postsynaptic properties of reticular neurons through both α1- and α2-adrenoreceptors. The α1-adrenoreceptor agonist phenylephrine (PE) activated an inward current in the presence of TTX and increased the frequency of both inhibitory and excitatory miniature postsynaptic currents. The α2-adrenoreceptor agonist dexmedetomidine (DMT) inhibited cNST-evoked excitatory currents as well as spontaneous and miniature excitatory currents through presynaptic mechanisms. The diversity of adrenoreceptor modulation of these prehypoglossal neurons may reflect their role in a multifunctional circuit coordinating both ingestive and respiratory lingual function.
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影响因子：
5.5
作者：
MADISON, DV;NICOLL, RA
通讯作者：
NICOLL, RA
影响因子：
5
作者：
Hikasa Yoshiaki;Akiba Tooru;Iino Yoshihisa;Matsukura Motoharu;Takase Katsuaki;Ogasawara Shigeo
通讯作者：
Hikasa Yoshiaki;Akiba Tooru;Iino Yoshihisa;Matsukura Motoharu;Takase Katsuaki;Ogasawara Shigeo
GABAB 受体在体内舌下运动神经元控制中的作用。
影响因子：
1.7
作者：
Okabe,S;Woch,G;Kubin,L
通讯作者：
Kubin,L
胃肠道和代谢对膳食量控制的神经学分离。
影响因子：
1.9
作者：
Seeley,RJ;Grill,HJ;Kaplan,JM
通讯作者：
Kaplan,JM
新生大鼠器官附着脑干块制剂在体外引发吞咽样活动
影响因子：
2.9
作者：
M. Kogo;T. Yamanishi;H. Koizumi;T. Matsuya
通讯作者：
T. Matsuya