Object-Displacement-Sensitive Visual Neurons Drive Freezing in Drosophila.
Object-Displacement-Sensitive Visual Neurons Drive Freezing in Drosophila.
复制标题
DOI：
10.1016/j.cub.2020.04.068
复制
发表时间：
2020-07-06
期刊：
影响因子：
--
通讯作者：
Clark DA
中科院分区：
文献类型：
--
作者：
Tanaka R;Clark DA
视觉系统通常配备有检测小型移动物体的神经元，这些物体可能代表猎物、捕食者或同种动物。虽然这些神经元的处理特性已经在不同的生物体中进行了研究，但所提出的算法与动物行为或电路机制之间的联系仍然难以捉摸。在这里，我们研究了果蝇中对象选择神经元 LC11 的行为功能、计算算法和神经化学机制。通过基因沉默和光遗传学激活，我们发现 LC11 对于行走果蝇的视觉物体诱导的停止行为（一种短期冻结的形式）是必需的，并且其活性可以促进停止。我们基于 LC11 的生理学和解剖学及其输入，提出了一种新的小物体选择性定量模型。该模型通过汇集快速适应、尺寸严格调整的输入，准确地再现 LC11 响应。 LC11 神经递质输入的直接可视化证实了有关上游处理的模型猜想。我们的结果证明了适应如何增强对行为相关的动态视觉特征的选择性。田中和克拉克表明，果蝇在看到移动的小物体时会启动短暂的冻结。这种行为取决于 LC11 神经元，LC11 神经元对翻译对象表现出高选择性，这是现有对象选择性神经元模型所没有预料到的。尺寸调整、快速适应单元的空间池解释了观察到的选择性。
Visual systems are often equipped with neurons that detect small moving objects, which may represent prey, predators, or conspecifics. While the processing properties of those neurons have been studied in diverse organisms, links between the proposed algorithms and animal behaviors or circuit mechanisms remain elusive. Here, we have investigated behavioral function, computational algorithm, and neurochemical mechanisms of an object-selective neuron, LC11, in Drosophila. With genetic silencing and optogenetic activation, we show that LC11 is necessary for a visual object-induced stopping behavior in walking flies, a form of short-term freezing, and its activity can promote stopping. We propose a new quantitative model for small object selectivity based on the physiology and anatomy of LC11 and its inputs. The model accurately reproduces LC11 responses by pooling fast-adapting, tightly size-tuned inputs. Direct visualization of neurotransmitter inputs to LC11 confirmed the model conjectures about upstream processing. Our results demonstrate how adaptation can enhance selectivity for behaviorally relevant, dynamic visual features. Tanaka and Clark show that Drosophila initiates brief freezing upon sighting small moving objects. This behavior depends on LC11 neurons, which show a high selectivity for translating objects that is not expected from existing models of object selective neurons. Spatial pooling of size-tuned, fast-adapting units explains the observed selectivity.
登录
查看更多内容
影响因子：
16.2
作者：
Coen, Philip;Xie, Marjorie;Clemens, Jan;Murthy, Mala
通讯作者：
Murthy, Mala
影响因子：
16.2
作者：
Creamer MS;Mano O;Clark DA
通讯作者：
Clark DA
影响因子：
64.8
作者：
Behnia, Rudy;Clark, Damon A.;Carter, Adam G.;Clandinin, Thomas R.;Desplan, Claude
通讯作者：
Desplan, Claude
DOI：
10.1073/pnas.1607601113
发表时间：
2016-10-18
影响因子：
11.1
作者：
Berman, Gordon J.;Bialek, William;Shaevitz, Joshua W.
通讯作者：
Shaevitz, Joshua W.
影响因子：
16.2
作者：
Freifeld L;Clark DA;Schnitzer MJ;Horowitz MA;Clandinin TR
通讯作者：
Clandinin TR