Theory of mind skills are related to gray matter volume in the ventromedial prefrontal cortex in schizophrenia.
Theory of mind skills are related to gray matter volume in the ventromedial prefrontal cortex in schizophrenia.
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DOI：
10.1016/j.biopsych.2011.07.027
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发表时间：
2011-12-15
影响因子：
10.6
通讯作者：
Vinogradov, Sophia
中科院分区：
文献类型：
--
作者：
Hooker, Christine I.;Bruce, Lori;Lincoln, Sarah Hope;Fisher, Melissa;Vinogradov, Sophia
在精神分裂症患者中，心理理论（ToM）技能的缺陷预示着社会功能较差。因此，确定 ToM 的神经基础可能有助于开发改善社会结果的治疗方法。尽管越来越多的证据表明腹内侧前额叶皮层 (VMPFC) 有助于健康个体的 ToM 技能，但方法上的挑战，例如一般认知缺陷的影响，使得很难确定精神分裂症中 ToM 处理和 VMPFC 功能之间的关系。我们使用基于体素的形态测量（VBM）和 ToM 处理的多方法行为评估，包括基于表现的（失礼识别测试）、自我报告（人际反应指数、观点采择）和访谈评级（生活质量量表-同理心得分）ToM 评估，以调查 ToM 技能是否与 VMPFC 灰质体积（GMV）相关。使用标准化的神经心理学测量来评估整体认知。 21 名精神分裂症患者和 17 名健康对照受试者参加了研究。组间行为分析表明，与健康参与者相比，精神分裂症参与者的 ToM 表现更差，日常生活中自我报告的 ToM 处理也更低。 GMV 的组间分析显示，精神分裂症参与者的 VMPFC GMV 低于健康参与者。此外，在精神分裂症参与者中，ToM 处理的所有三个指标都与 VMPFC GMV 相关，因此较差的 ToM 技能与较少的 VMPFC GMV 相关。即使在控制全局认知的影响的情况下，自我报告和面试评价的 ToM 技能的这种关联仍然很强。研究结果表明，在精神分裂症患者中，VMPFC GMV 降低与使用 ToM 技能增强社交关系的缺陷特别相关。
Among individuals with schizophrenia, deficits in theory of mind (ToM) skills predict poor social functioning. Therefore, identifying the neural basis of ToM may assist the development of treatments that improve social outcomes. Despite growing evidence that the ventromedial prefrontal cortex (VMPFC) facilitates ToM skills among healthy individuals, methodological challenges, such as the influence of general cognitive deficits, have made it difficult to identify the relationship between ToM processing and VMPFC function in schizophrenia. We used voxel-based morphometry (VBM) and a multi-method behavioral assessment of ToM processing, including performance-based (Recognition of Faux Pas Test), self-report (Interpersonal Reactivity Index, Perspective-Taking), and interview-rated (Quality of Life Scale–Empathy score) ToM assessments, to investigate whether ToM skills were related to VMPFC gray matter volume (GMV). Standardized neuropsychological measures were used to assess global cognition. 21 schizophrenia and 17 healthy control subjects participated. Between-group behavioral analyses showed that, as compared to healthy participants, schizophrenia participants had worse ToM performance and lower self-reported ToM processing in daily life. The between-group analysis of GMV showed that schizophrenia participants had less VMPFC GMV than healthy participants. Moreover, among schizophrenia participants, all three measures of ToM processing were associated with VMPFC GMV, such that worse ToM skills were related to less VMPFC GMV. This association remained strong for self-reported and interview-rated ToM skills even when controlling for the influence of global cognition. The findings suggest that among individuals with schizophrenia, reduced VMPFC GMV is specifically associated with deficits using ToM skills to enhance social relationships.
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