Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study.
Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study.
复制标题
DOI：
10.1186/s12885-015-1153-9
复制
发表时间：
2015-03-26
期刊：
影响因子：
3.8
通讯作者：
Raaschou-Nielsen O
中科院分区：
文献类型：
--
作者：
Eriksen KT;Halkjær J;Meliker JR;McElroy JA;Sørensen M;Tjønneland A;Raaschou-Nielsen O
根据高暴露职业环境的证据，镉被归类为人类肺部致癌物。虽然镉没有生理作用，但越来越多的证据表明镉可能类似于类固醇激素。这种致癌性和类镉的双重能力使镉成为与镉相关的癌症的关注点。前列腺癌的病因尚不清楚，但类固醇激素，特别是雄激素，可能与雌激素有关。在职业暴露的男性中，镉与前列腺癌呈正相关。在非职业暴露人群中，饮食和吸烟是镉暴露的主要来源。本研究的目的是调查丹麦男性饮食中镉摄入量与前列腺癌风险之间的关系。在1993-97年基线时，对丹麦饮食、癌症和健康队列的饮食镉摄入量进行了估计。这些估计是基于192项半定量食物频率问卷和所有食物中的镉含量。在26,778名男性中，我们使用丹麦癌症登记处从基线到2010年12月31日确定了1,567例前列腺癌病例。采用考克斯回归模型分析了饮食中镉摄入量与前列腺癌风险之间的关系。我们没有发现饮食中镉摄入量与前列腺癌风险之间存在关联（每10 μg/天的校正发病率比= 0.98（95% CI = 0.88-1.10））。根据前列腺癌的侵袭性，这种关联没有差异。教育水平、吸烟状况、体重指数、锌或铁的摄入量并没有改变这种关联。在我们的研究中，我们没有发现丹麦男性队列中饮食镉摄入量与前列腺癌风险之间存在关联。
Cadmium is classified as a human lung carcinogen based on evidence from high-exposure occupational settings. Though cadmium has no physiological role, increasing evidence suggests cadmium may mimic steroid hormones. This dual ability of being carcinogenic and hormone-like makes cadmium a concern for hormone-related cancers. Causes of prostate cancer are not clear, but steroid hormones, particularly androgens and probably estrogens, may be involved. Cadmium has been positively associated with prostate cancer in occupationally exposed men. In non-occupationally exposed populations, diet and smoking are the main sources of cadmium exposure. The aim of this study was to investigate the association between dietary cadmium intake and prostate cancer risk in Danish men. Dietary cadmium intake was estimated in the Danish Diet, Cancer and Health cohort at baseline 1993–97. The estimates were based on a 192 item semi-quantitative food frequency questionnaire and cadmium contents in all food items. Among 26,778 men we identified 1,567 prostate cancer cases from baseline through December 31, 2010 using the Danish Cancer Registry. The association between dietary cadmium intake and prostate cancer risk was analysed using Cox regression models. We did not find an association between dietary cadmium intake and prostate cancer risk (adjusted incidence rate ratio per 10 μg day−1 = 0.98 (95% CI = 0.88-1.10)). The association did not differ according to aggressiveness of prostate cancer. Educational level, smoking status, BMI, zinc or iron intake did not modify the association. In our study, we did not find an association between dietary cadmium intake and prostate cancer risk in a cohort of Danish men.
登录
查看更多内容
影响因子：
10.3
作者：
Martínez-Campa, C;Alonso-González, C;Sánchez-Barceló, EJ
通讯作者：
Sánchez-Barceló, EJ
影响因子：
2.8
作者：
Platz, EA;Helzlsouer, KJ;Comstock, GW
通讯作者：
Comstock, GW
DOI：
10.1111/j.1749-6632.1976.tb23122.x
发表时间：
1976-01-01
影响因子：
5.2
作者：
LEMEN, RA;LEE, JS;BLEJER, HP
通讯作者：
BLEJER, HP
影响因子：
4.1
作者：
Brama, Marina;Gnessi, Lucio;Migliaccio, Silvia
通讯作者：
Migliaccio, Silvia
DOI：
10.1016/0002-9378(90)90420-c
发表时间：
1990-02-01
影响因子：
9.8
作者：
BARON, JA;LAVECCHIA, C;LEVI, F
通讯作者：
LEVI, F