Adaptation and shunting inhibition leads to pyramidal/interneuron gamma with sparse firing of pyramidal cells
Adaptation and shunting inhibition leads to pyramidal/interneuron gamma with sparse firing of pyramidal cells
复制标题
适应和分流抑制导致锥体/中间神经元伽玛，锥体细胞稀疏放电
DOI：
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发表时间：
2014
影响因子：
1.2
通讯作者：
B. Gutkin
中科院分区：
文献类型：
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作者：
M. Krupa;S. Gielen;B. Gutkin
伽马振荡是一种与许多大脑功能相关的突出现象。数据显示，单个锥体神经元可以以低于伽马的速率发射，群体显示出明显的伽马振荡和同步性。在这种弱伽马射线的一种理想化模型中，锥体神经元成簇放电。在这里，我们提供了一个理论，集群伽马PING节奏强抑制和较弱的兴奋。我们的生物物理模型的模拟表明，锥体神经元的适应加上他们的低放电率导致集群的形成。正则模型的部分解析研究表明，相位响应曲线与近零平坦区，所造成的慢自适应电流的存在下，是形成集群的关键。此外，我们研究分流抑制，并表明集群变得强大和通用
Gamma oscillations are a prominent phenomenon related to a number of brain functions. Data show that individual pyramidal neurons can fire at rate below gamma with the population showing clear gamma oscillations and synchrony. In one kind of idealized model of such weak gamma, pyramidal neurons fire in clusters. Here we provide a theory for clustered gamma PING rhythms with strong inhibition and weaker excitation. Our simulations of biophysical models show that the adaptation of pyramidal neurons coupled with their low firing rate leads to cluster formation. A partially analytic study of a canonical model shows that the phase response curves with a near zero flat region, caused by the presence of the slow adaptive current, are the key to the formation of clusters. Furthermore we examine shunting inhibition and show that clusters become robust and generic
影响因子：
33.6
作者：
Wang XJ
通讯作者：
Wang XJ
DOI：
10.1073/pnas.0502366102
发表时间：
2005-05-10
影响因子：
11.1
作者：
Börgers, C;Epstein, S;Kopell, NJ
通讯作者：
Kopell, NJ