E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus.
E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus.
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DOI：
10.1038/bjc.1995.34
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发表时间：
1995-01
影响因子：
8.8
通讯作者：
Beer, D. G.
中科院分区：
文献类型：
--
作者：
Bongiorno, P. F.;Al-Kasspooles, M.;Lee, S. W.;Rachwal, W. J.;Moore, J. H.;Whyte, R. I.;Orringer, M. B.;Beer, D. G.
e -钙粘蛋白（一种存在于正常上皮中的Ca（2+）依赖性细胞粘附分子）的表达减少与侵袭性和转移性癌症有关。应用免疫组化方法检测59例食管癌和52例肺癌E-cadherin表达与分期的关系。晚期食管癌与E-cadherin表达减少和无组织相关（P < 0.01）。晚期肺腺癌普遍表现为E-cadherin表达紊乱或降低，但表达模式与分期无统计学相关性（P < 0.05）。在e -钙粘蛋白表达减少或紊乱的肿瘤中，分期没有差异。在发育不良的非侵袭性Barrett食管中检测到E-cadherin表达改变。重要的是，在17个含有转移性癌的淋巴结中，有17个检测到高水平的E-cadherin表达。E-cadherin mRNA在蛋白表达降低的肿瘤中表达降低，但在表达紊乱的肿瘤中没有。在E-cadherin蛋白表达改变的组织中，检测到E-cadherin相关蛋白α -catenin mRNA的表达。e -钙粘蛋白表达的减少和紊乱似乎分别与转录和翻译后事件有关，两者似乎都代表了与胸部肿瘤侵袭和转移相关的细胞粘附改变。
Reduced expression of E-cadherin, a Ca(2+)-dependent cell adhesion molecule present in normal epithelium, has been associated with invasive and metastatic cancer. Immunohistochemistry was used in examining the relationship between E-cadherin expression and stage in 59 oesophageal and 52 lung cancers. Advanced-stage oesophageal cancers were associated with both reduced and disorganised E-cadherin expression (P < 0.01). Advanced-stage lung adenocarcinomas generally exhibited disorganised or reduced E-cadherin expression, but no statistical association between expression pattern and stage was found (P > 0.05). No differences in stage were seen between tumours with reduced or disorganised E-cadherin expression. Altered E-cadherin expression was detected in dysplastic, non-invasive Barrett's oesophagus. Importantly, high-level E-cadherin expression was detected in 17 of 17 lymph nodes containing metastatic cancer. E-cadherin mRNA expression was decreased in tumours with reduced protein expression, but not in tumours with disorganised expression. Expression of alpha-catenin mRNA, an E-cadherin-associated protein, was detected in tissues with altered E-cadherin protein expression. Reduced and disorganised expression of E-cadherin appear to be related to transcriptional and post-translational events respectively, and both appear to represent altered cell adhesion associated with invasion and metastasis in thoracic neoplasms.
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影响因子：
8.8
作者：
Matsuura, K;Kawanishi, J;Fujii, S;Imamura, M;Hirano, S;Takeichi, M;Niitsu, Y
通讯作者：
Niitsu, Y
DOI：
10.1083/jcb.118.5.1213
发表时间：
1992-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lee SW;Tomasetto C;Paul D;Keyomarsi K;Sager R
通讯作者：
Sager R
DOI：
10.1083/jcb.108.6.2435
发表时间：
1989-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Behrens J;Mareel MM;Van Roy FM;Birchmeier W
通讯作者：
Birchmeier W
影响因子：
64.5
作者：
HIRANO, S;KIMOTO, N;TAKEICHI, M
通讯作者：
TAKEICHI, M
影响因子：
64.5
作者：
NAGAFUCHI, A;TAKEICHI, M;TSUKITA, S
通讯作者：
TSUKITA, S