Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia.
Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia.
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DOI：
10.1186/1471-2202-10-85
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发表时间：
2009-07-20
期刊：
影响因子：
2.4
通讯作者：
McCarley RW
中科院分区：
文献类型：
--
作者：
Spencer KM;Niznikiewicz MA;Nestor PG;Shenton ME;McCarley RW
振荡脑电图（EEG）异常可能反映神经回路功能障碍的神经精神疾病。以前，我们已经发现β和γ振荡的相位同步和精神分裂症患者的幻觉症状之间的正相关。这些发现表明，幻觉的倾向与感觉皮层中的神经回路进入振荡同步状态的趋势增加有关。在这里，我们测试了这一假设，检查是否40赫兹听觉稳态反应（ASSR）产生的左初级听觉皮层与幻听症状的精神分裂症呈正相关。我们还研究了精神分裂症患者的40 Hz ASSR缺陷是否与交叉频率相互作用有关。16名健康对照者（HC）和18名慢性精神分裂症患者（SZ）听40 Hz双耳短声训练。从60个电极记录EEG，并离线参考平均值。根据HC总平均ASSR拟合5偶极子模型，其中2对上级颞偶极子和1对深中线偶极子。对头皮EEG和源数据进行时频分解。在额中央电极，SZ的锁相因子（PLF）和诱发功率降低，复制先前的研究结果。对于非同源的左右半球来源，SZ的PLF减少。SZ的左半球源性PLF与幻听症状呈正相关，并受δ相位调制。此外，源诱发功率和PLF之间的相关性，发现在HC减少SZ的LH源。这些发现表明，差异神经回路异常可能存在于左，右听觉皮层精神分裂症。此外，他们提供了进一步的支持假说，即幻觉与皮质过度兴奋，这是表现为增加的倾向，在特定模态的皮质区的高频同步。
Oscillatory electroencephalogram (EEG) abnormalities may reflect neural circuit dysfunction in neuropsychiatric disorders. Previously we have found positive correlations between the phase synchronization of beta and gamma oscillations and hallucination symptoms in schizophrenia patients. These findings suggest that the propensity for hallucinations is associated with an increased tendency for neural circuits in sensory cortex to enter states of oscillatory synchrony. Here we tested this hypothesis by examining whether the 40 Hz auditory steady-state response (ASSR) generated in the left primary auditory cortex is positively correlated with auditory hallucination symptoms in schizophrenia. We also examined whether the 40 Hz ASSR deficit in schizophrenia was associated with cross-frequency interactions. Sixteen healthy control subjects (HC) and 18 chronic schizophrenia patients (SZ) listened to 40 Hz binaural click trains. The EEG was recorded from 60 electrodes and average-referenced offline. A 5-dipole model was fit from the HC grand average ASSR, with 2 pairs of superior temporal dipoles and a deep midline dipole. Time-frequency decomposition was performed on the scalp EEG and source data. Phase locking factor (PLF) and evoked power were reduced in SZ at fronto-central electrodes, replicating prior findings. PLF was reduced in SZ for non-homologous right and left hemisphere sources. Left hemisphere source PLF in SZ was positively correlated with auditory hallucination symptoms, and was modulated by delta phase. Furthermore, the correlations between source evoked power and PLF found in HC was reduced in SZ for the LH sources. These findings suggest that differential neural circuit abnormalities may be present in the left and right auditory cortices in schizophrenia. In addition, they provide further support for the hypothesis that hallucinations are related to cortical hyperexcitability, which is manifested by an increased propensity for high-frequency synchronization in modality-specific cortical areas.
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DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.
影响因子：
9.9
作者：
Geyer, JD;Bilir, E;Gilliam, F
通讯作者：
Gilliam, F
影响因子：
5.7
作者：
Herdman, AT;Wollbrink, A;Pantev, C
通讯作者：
Pantev, C
影响因子：
3.7
作者：
Hoffman, Ralph E.;Hampson, Michelle;Krystal, John H.
通讯作者：
Krystal, John H.
影响因子：
--
作者：
Hirayasu, Y;McCarley, RW;Shenton, ME
通讯作者：
Shenton, ME