The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation
The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation
复制标题
天然化合物 Withaferin A 与 β-微管蛋白的 Cys239 共价结合,促进微管蛋白降解
DOI:
10.1124/mol.119.117812
复制
发表时间:
2019-10
影响因子:
3.6
通讯作者:
陈俐娟
中科院分区:
文献类型:
--
作者:
杨建洪;闫伟;黎勇;牛璐;叶昊宇;陈俐娟
Withaferin A (WIT) is a natural product possessing a wide range of pharmacologic activities. Previous studies have reported covalent binding of WIT to tubulin and down-of tubulin protein levels although the underlying mechanisms remain to be established.
登录
查看更多内容
影响因子:
13.3
作者:
Stanton, Richard A.;Gernert, Kim M.;Nettles, James H.;Aneja, Ritu
通讯作者:
Aneja, Ritu
影响因子:
16.6
作者:
Yang J;Wang Y;Wang T;Jiang J;Botting CH;Liu H;Chen Q;Yang J;Naismith JH;Zhu X;Chen L
通讯作者:
Chen L
影响因子:
16
作者:
Ya-Ling Wu;Xiaojing Yang;Zhong Ren;D. McDonnell;J. Norris;T. Willson;G. Greene
通讯作者:
Ya-Ling Wu;Xiaojing Yang;Zhong Ren;D. McDonnell;J. Norris;T. Willson;G. Greene
DOI:
10.2174/1573406411666151030112314
发表时间:
2016-05
期刊:
Medicinal chemistry (Shariqah (United Arab Emirates))
影响因子:
--
作者:
S. Khan;S. Khan;Zarbad Shah;Abdullah M. Asiri
通讯作者:
S. Khan;S. Khan;Zarbad Shah;Abdullah M. Asiri
DOI:
10.1016/s0021-9258(18)34031-6
发表时间:
1982-09
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
G. Na;S. N. Timasheff
通讯作者:
G. Na;S. N. Timasheff