Macrophages with cellular backpacks for targeted drug delivery to the brain.
Macrophages with cellular backpacks for targeted drug delivery to the brain.
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DOI：
10.1016/j.biomaterials.2017.06.017
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发表时间：
2017-09
期刊：
影响因子：
14
通讯作者：
Batrakova EV
中科院分区：
文献类型：
--
作者：
Klyachko NL;Polak R;Haney MJ;Zhao Y;Gomes Neto RJ;Hill MC;Kabanov AV;Cohen RE;Rubner MF;Batrakova EV
大多数有效的治疗药物在全身给药后无法跨越血脑屏障，这就需要开发非常规的、临床适用的药物输送系统。在给定的挑战下，具有生物活性的飞行器对于完成这项任务至关重要。我们现在报道一种新的药物输送方法，它利用活细胞作为药物穿越血脑屏障的载体。细胞背包，直径7-10微米，厚度数百纳米的聚合物贴片，是一种潜在的有趣方法，因为它们可以充当药物仓库，与细胞载体一起运输，而不被吞噬。背包里装着一种强大的抗氧化剂过氧化氢酶，它们被附着在自体巨噬细胞上，并系统地给有脑部炎症的小鼠注射。通过使用炎症反应细胞，可以将药物定向输送到发炎的大脑。此外，装载过氧化氢酶的背包在体外显示出有效的治疗作用，可以抑制激活的小胶质细胞释放的自由基。这种药物携带和释放的方法可以加速针对所有神经退行性疾病的新药制剂的开发。
Most potent therapeutics are unable to cross the blood-brain barrier following systemic administration, which necessitates the development of unconventional, clinically applicable drug delivery systems. With the given challenges, biologically active vehicles are crucial to accomplishing this task. We now report a new method for drug delivery that utilizes living cells as vehicles for drug carriage across the blood brain barrier. Cellular backpacks, 7–10 µm diameter polymer patches of a few hundred nanometers in thickness, are a potentially interesting approach, because they can act as drug depots that travel with the cell-carrier, without being phagocytized. Backpacks loaded with a potent antioxidant, catalase, were attached to autologous macrophages and systemically administered into mice with brain inflammation. Using inflammatory response cells enabled targeted drug transport to the inflamed brain. Furthermore, catalase-loaded backpacks demonstrated potent therapeutic effects deactivating free radicals released by activated microglia in vitro. This approach for drug carriage and release can accelerate the development of new drug formulations for all the neurodegenerative disorders.
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影响因子：
17.1
作者：
Hsu BB;Conway W;Tschabrunn CM;Mehta M;Perez-Cuevas MB;Zhang S;Hammond PT
通讯作者：
Hammond PT
影响因子：
3.7
作者：
Batrakova, EV;Han, HY;Kabanov, AV
通讯作者：
Kabanov, AV
DOI：
10.2217/nnm.13.115
发表时间：
2014-07
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Klyachko NL;Haney MJ;Zhao Y;Manickam DS;Mahajan V;Suresh P;Hingtgen SD;Mosley RL;Gendelman HE;Kabanov AV;Batrakova EV
通讯作者：
Batrakova EV
影响因子：
5.4
作者：
Klyachko, Natalia L.;Manickam, Devika S.;Brynskikh, Anna M.;Uglanova, Svetlana V.;Li, Shu;Higginbotham, Sheila M.;Bronich, Tatiana K.;Batrakova, Elena V.;Kabanov, Alexander V.
通讯作者：
Kabanov, Alexander V.
影响因子：
4.7
作者：
Batrakova, Elena V.;Li, Shu;Gendelman, Howard E.
通讯作者：
Gendelman, Howard E.