Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse.
Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse.
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DOI：
10.1038/s41541-023-00761-4
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发表时间：
2023-10-28
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
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作者：
治疗性疫苗有望作为结核病的辅助治疗或预防结核病复发。一个重要的发展挑战是对辅助性T细胞（Th）在这些疾病阶段的作用的了解有限。用小鼠结核病复发模型来鉴定Th群和细胞因子微环境的变化。活动性结核病促进Th1、Th2、Th17和Th22细胞和细胞因子在肺中的扩张。药物治疗后，肺部Th17和Th22细胞收缩，Th1细胞保持升高，而产生IL-4或IL-10的Th细胞扩增。在复发时，尽管Th1和Th17细胞有适度的再扩张，并且Th细胞因子多功能性增加，但Th22细胞未能在肺中再扩张。种群的动态进一步因组织腔室和疾病表现而不同。这些结果确定了结核病复发期间Th亚群的免疫偏倚是发病机制和治疗性疫苗接种的候选机制。
Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease. A murine model of TB relapse was used to identify changes in Th populations and cytokine microenvironment. Active TB promoted expansion of Th1, Th2, Th17, and Th22 cells and cytokines in the lung. Following drug therapy, pulmonary Th17 and Th22 cells contracted, Th1 cells remained elevated, while Th cells producing IL-4 or IL-10 expanded. At relapse, Th22 cells failed to re-expand in the lung despite a moderate re-expansion of Th1 and Th17 cells and an increase in Th cytokine polyfunctionality. The dynamics of Th populations further differed by tissue compartment and disease presentation. These outcomes identify immune bias by Th subpopulations during TB relapse as candidate mechanisms for pathogenesis and targets for therapeutic vaccination.
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DOI：
10.4049/jimmunol.1202580
发表时间：
2013-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Niedbala W;Besnard AG;Jiang HR;Alves-Filho JC;Fukada SY;Nascimento D;Mitani A;Pushparaj P;Alqahtani MH;Liew FY
通讯作者：
Liew FY
影响因子：
7.3
作者：
Ronacher K;Sinha R;Cestari M
通讯作者：
Cestari M
DOI：
10.1111/j.1440-1843.2010.01739.x
发表时间：
2010-04
期刊：
Respirology (Carlton, Vic.)
影响因子：
--
作者：
Dheda K;Schwander SK;Zhu B;van Zyl-Smit RN;Zhang Y
通讯作者：
Zhang Y
影响因子：
6.7
作者：
Bold TD;Banaei N;Wolf AJ;Ernst JD
通讯作者：
Ernst JD
DOI：
10.1016/j.tube.2011.05.007
发表时间：
2011-11
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
Bark CM;Dietze R;Okwera A;Quelapio MI;Thiel BA;Johnson JL
通讯作者：
Johnson JL