Microfluidic systems to study tissue barriers to immunotherapy.
Microfluidic systems to study tissue barriers to immunotherapy.
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DOI：
10.1007/s13346-021-01016-2
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发表时间：
2021-12
影响因子：
5.4
通讯作者：
Maisel, Katharina
中科院分区：
文献类型：
--
作者：
Ramirez, Ann;Amosu, Mayowa;Lee, Priscilla;Maisel, Katharina
在过去的十年中，免疫疗法得到了广泛的探索，从癌症的新疗法到过敏性疾病。这些疗法针对免疫系统，这是一个复杂的器官系统，由结构复杂的组织和具有多种功能的细胞组成。为了更好地了解免疫功能并开发更好的治疗方法，人们开发了许多细胞和二维 (2D) 组织模型。然而，研究表明，3 维 (3D) 组织结构可以显着影响细胞功能，而更传统的 2D 模型无法概括这一点。微流体已用于设计 3D 组织模型，允许细胞和细胞外空间的复杂排列，从而允许更生理相关的体外模型系统。在这里，我们总结了多种旨在研究免疫系统的微流体装置，最终目标是改进现有的免疫疗法并设计新的免疫疗法。我们包括不同免疫器官的模型，包括骨髓和淋巴结 (LN)、癌症和炎症性肠病等疾病的免疫模型，以及测试或设计新的免疫调节疗法的治疗模型。我们特别强调如何使用微流体装置来更好地了解不同的生理状态以及免疫微环境内的相互作用如何影响免疫疗法的功效。
Immunotherapies have been heavily explored in the last decade, ranging from new treatments for cancer to allergic diseases. These therapies target the immune system, a complex organ system consisting of tissues with intricate structures and cells with a multitude of functions. To better understand immune functions and develop better therapeutics, many cellular and 2-dimensional (2D) tissue models have been developed. However, research has demonstrated that the 3-dimensional (3D) tissue structure can significantly affect cellular functions, and this is not recapitulated by more traditional 2D models. Microfluidics has been used to design 3D tissue models that allow for intricate arrangements of cells and extracellular spaces, thus allowing for more physiologically relevant in vitro model systems. Here, we summarize the multitude of microfluidic devices designed to study the immune system with the ultimate goal to improve existing and design new immunotherapies. We have included models of the different immune organs, including bone marrow and lymph node (LN), models of immunity in diseases such as cancer and inflammatory bowel disease, and therapeutic models to test or engineer new immune-modulatory treatments. We particularly emphasize research on how microfluidic devices are used to better understand different physiological states and how interactions within the immune microenvironment can influence the efficacy of immunotherapies.
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影响因子：
3.1
作者：
Breslin, Jerome W.
通讯作者：
Breslin, Jerome W.
影响因子：
14.8
作者：
Bounab, Yacine;Eyer, Klaus;Vedrine, Christophe
通讯作者：
Vedrine, Christophe
影响因子：
6.1
作者：
Gjorevski, Nikolce;Avignon, Blandine;Moisan, Annie
通讯作者：
Moisan, Annie
DOI：
10.1126/science.1188302
发表时间：
2010-06-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Huh D;Matthews BD;Mammoto A;Montoya-Zavala M;Hsin HY;Ingber DE
通讯作者：
Ingber DE
影响因子：
1.5
作者：
Cesta, Mark F.
通讯作者：
Cesta, Mark F.