Advances in microfluidic materials, functions, integration, and applications.
Advances in microfluidic materials, functions, integration, and applications.
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DOI：
10.1021/cr300337x
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发表时间：
2013-04-10
期刊：
影响因子：
62.1
通讯作者：
Woolley, Adam T.
中科院分区：
文献类型：
--
作者：
Nge, Pamela N.;Rogers, Chad I.;Woolley, Adam T.
微流体由用于液体处理的微制造结构组成，其横截面在1-500 μm范围内，体积容量小（飞升到纳升）。与配件连接的毛细管，(1)虽然使用的体积很小，但在本文中不被认为是微流体，因为它们不是微制造的。同样，由传统加工工具制成的微流体系统由于其更大的特征尺寸（> 500 μm）而被排除在外。虽然用于气相色谱的微机械系统在20世纪70年代被引入，但直到20世纪90年代，微流体领域才获得很大的关注。(3)硅和玻璃是最初使用的材料，但后来重点转移到包括聚合物衬底，特别是聚二甲基硅氧烷（PDMS）。从那时起，该领域已经发展到包括各种各样的材料和应用。电泳和电渗泵在微流体装置中的成功演示为流体控制和分离提供了一种非机械的方法。(4)激光诱导荧光（LIF）可以灵敏地检测荧光团或荧光标记分子。低成本印刷的扩大使得在软光刻中使用的掩膜制造更便宜和更快。(5)商业微流控系统现在可以从雅培，安捷伦，卡佩尔，Dolomite, Micralyne，微流控芯片商店，Micrux技术和沃特斯，作为几个突出的例子。为了更彻底地描述微流体的历史，我们建议读者参考一些全面的，专门的评论，（3,6 -11）以及更一般的2006年评论。(12）
Microfluidics consist of microfabricated structures for liquid handling, with cross sections in the 1–500 μm range and small volume capacity (femtoliter to nanoliter). Capillary tubes connected with fittings,(1) although utilizing small volumes, are not considered microfluidics for the purposes of this paper since they are not microfabricated. Likewise, millifluidic systems made by conventional machining tools are excluded due to their larger feature sizes (> 500 μm).Though micromachined systems for gas chromatography were introduced in the 1970s,(2) the field of microfluidics did not gain much traction until the 1990s.(3) Silicon and glass were the original materials used, but then the focus shifted to include polymer substrates, and in particular, polydimethylsiloxane (PDMS). Since then the field has grown to encompass a wide variety of materials and applications. The successful demonstration of electrophoresis and electroosmotic pumping in a microfluidic device provided a nonmechanical method for both fluid control and separation.(4) Laser-induced fluorescence (LIF) enabled sensitive detection of fluorophores or fluorescently labeled molecules. The expanded availability of low-cost printing allowed for cheaper and quicker mask fabrication for use in soft lithography.(5) Commercial microfluidic systems are now available from Abbott, Agilent, Caliper, Dolomite, Micralyne, Microfluidic Chip Shop, Micrux Technologies, and Waters, as a few prominent examples. For a more thorough description of the history of microfluidics, we refer the reader to a number of comprehensive, specialized reviews,(3, 6-11) as well as a more general 2006 review.(12)
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影响因子：
6.1
作者：
Ahmed, Daniel;Mao, Xiaole;Huang, Tony Jun
通讯作者：
Huang, Tony Jun
影响因子：
6.1
作者：
Bottenus D;Hossan MR;Ouyang Y;Dong WJ;Dutta P;Ivory CF
通讯作者：
Ivory CF
影响因子：
6.1
作者：
Araci, Ismail Emre;Quake, Stephen R.
通讯作者：
Quake, Stephen R.
影响因子：
2.9
作者：
Armenta, Jenny M.;Dawoud, Abdulilah A.;Lazar, Iulia M.
通讯作者：
Lazar, Iulia M.
影响因子：
4.3
作者：
Baldini, F.;Carloni, A.;Trono, C.
通讯作者：
Trono, C.