Wood dust exposure and risk of lung cancer.
Wood dust exposure and risk of lung cancer.
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DOI：
10.1136/oem.2010.060004
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发表时间：
2011-08
影响因子：
4.9
通讯作者：
Vaughan TL
中科院分区：
文献类型：
--
作者：
Bhatti P;Newcomer L;Onstad L;Teschke K;Camp J;Morgan M;Vaughan TL
尽管木尘和鼻窦癌之间有着令人信服的联系，但很少有系统和严格的研究木尘和肺癌之间的关系。我们调查了通过职业和爱好相关活动暴露于木尘的历史是否与肺癌风险增加相关。我们进行了一项以人群为基础的病例对照研究，其中440例病例通过弗雷德哈钦森癌症研究中心的癌症监测系统在华盛顿州西部从1993年到1996年确定，845例年龄匹配的对照通过随机数字拨号确定。使用详细的工作和个人历史，量化估计的累积接触木尘（被认为主要来自软木）计算每个参与者。使用无条件Logistic回归调整年龄和吸烟状况，肺癌的风险进行了检查，与木材相关的职业，工作与木材作为一种爱好，以及累积木尘暴露，考虑到职业和爱好相关的来源。虽然我们观察到与锯木厂工作相关的肺癌风险增加（OR=1.5; 95% CI：1.1，2.1），但我们没有发现其他职业风险增加的证据，将木材作为一种爱好或估计累积暴露于木尘（OR = 0.9; 95% CI：0.6，1.3，最高与最低四分位数相比）。与我们的假设相反，我们观察到适度的非显着降低风险与木材粉尘接触，虽然没有明显的剂量反应关系。这项研究提供了一些令人放心的证据，证明软木粉尘不会增加肺癌的风险，但未来的研究应该密切评估硬木粉尘的暴露。反向关联的提示性证据可能归因于木尘中存在内毒素，但缺乏剂量-反应关系表明存在非因果关系。
Despite the compelling association between wood dust and sinonasal cancer, there has been little systematic and rigorous study of the relationship between wood dust and lung cancer. We investigated whether a history of exposure to wood dust through occupational and hobby-related activities was associated with increased lung cancer risk. We conducted a population-based case-control study, with 440 cases, identified from 1993 to 1996 through the Fred Hutchinson Cancer Research Center Cancer Surveillance System for western Washington State, and 845 age-matched controls, identified by random-digit dialing. Using detailed work and personal histories, quantitative estimates of cumulative exposure to wood dust (thought to be primarily from softwood) were calculated for each participant. Using unconditional logistic regression adjusted for age and smoking status, risk of lung cancer was examined in relation to employment in wood-related occupations, working with wood as a hobby, as well as cumulative wood dust exposure that took into account both occupational and hobby-related sources. While we observed an increased risk of lung cancer associated with working in a sawmill (OR=1.5; 95% CI: 1.1, 2.1), we found no evidence of increased risks with other occupations, working with wood as a hobby or with estimated cumulative exposure to wood dust (OR = 0.9; 95% CI: 0.6, 1.3, for highest compared to lowest quartile of exposure). Contrary to our hypothesis, we observed modest non-significant decreased risks with exposure to wood dust, although no dose-response relationship was apparent. This study provided somewhat reassuring evidence that softwood dust does not increase the risk of lung cancer, but future studies should closely evaluate exposure to hardwood dusts. Suggestive evidence for an inverse association may be attributable to the presence of endotoxin in the wood dust, but the lack of a dose-response relationship suggests a non-causal relationship.
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影响因子：
4.5
作者：
Määttä, J;Luukkonen, R;Savolainen, K
通讯作者：
Savolainen, K
影响因子：
--
作者：
ACHESON, ED;COWDELL, RH;MACBETH, RG
通讯作者：
MACBETH, RG
DOI：
10.1080/15459620600793672
发表时间：
2006-08-01
影响因子：
2
作者：
Astrakianakis, George;Seixas, Noah;Checkoway, Harvey
通讯作者：
Checkoway, Harvey
影响因子：
6.3
作者：
HOLMSTROM, M;WILHELMSSON, B
通讯作者：
WILHELMSSON, B
影响因子：
4.9
作者：
Laakkonen, A.;Kyyronen, P.;Pukkala, E. I.
通讯作者：
Pukkala, E. I.