The role of depression in work-related outcomes of HIV treatment in Uganda.
The role of depression in work-related outcomes of HIV treatment in Uganda.
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DOI：
10.1007/s12529-013-9379-x
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发表时间：
2014-12
影响因子：
2.7
通讯作者：
Musisi S
中科院分区：
文献类型：
--
作者：
Wagner GJ;Ghosh-Dastidar B;Slaughter M;Akena D;Nakasujja N;Okello E;Musisi S
这项分析的主要目标是研究抑郁症的影响，超越艾滋病毒治疗对工作活动和功能的影响。我们结合了来自乌干达开始抗逆转录病毒治疗（ART）和/或进入HIV护理的患者的三项纵向研究的数据。在基线以及第6个月和第12个月进行评估。使用9项患者健康问卷（PHQ-9）评估抑郁症状以及重度（评分> 9）和轻度（评分5-9）抑郁状态;使用医学结局研究HIV健康调查（MOS-HIV）的子量表评估工作功能。纵向数据的多变量随机效应logistic回归模型用于检查治疗对工作状态和最佳工作功能的影响，测量模型中的基线和身体健康功能，认知功能和抑郁症的变化，控制基线人口统计学和CD 4细胞计数。1，731名参与者的样本包括1，204名开始ART的参与者和527名尚未符合ART的参与者。在基线时，35%的参与者没有工作，37%的参与者的工作功能不佳。意向治疗分析显示，相对于非ART患者，ART患者在12个月内的两项工作成果都有更大的改善，并且身体健康功能的基线和变化，持续和分类抑郁症都与两项工作成果的改善独立相关，即使在考虑了抗逆转录病毒疗法的直接影响之后，身心健康的改善在艾滋病毒治疗对工作活动和功能的积极影响中发挥着关键作用，这表明将抑郁症治疗纳入艾滋病护理的潜在经济效益。
The primary goal of this analysis was to examine the influence of depression above and beyond the effects of HIV treatment on work activity and function. We combined data from three longitudinal studies of patients starting antiretroviral therapy (ART) and/or entering HIV care in Uganda. Assessments were conducted at baseline and months 6 and 12. The 9-item Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms, as well as Major (scores > 9) and Minor (scores 5–9) Depression status; work functioning was assessed using a sub-scale of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Multivariate random-effects logistic regression models for longitudinal data were used to examine the impact of treatment on work status and optimal work functioning, with measures of both baseline and change in physical health functioning, cognitive functioning and depression in the models, controlling for baseline demographics and CD4 cell count. The sample of 1,731 participants consisted of 1,204 starting ART and 527 not yet eligible for ART. At baseline, 35% were not working and 37% had sub-optimal work functioning. Intention-to-treat analyses revealed that those on ART experienced greater improvement in both work outcomes over 12 months relative to non-ART patients, and that baseline and change in physical health functioning, continuous and categorical depression were all independently associated with improvement in both work outcomes, even after accounting for the direct effect of ART. Improvement in physical and mental health plays a key role in the positive impact of HIV treatment on work activity and function, suggesting potential economic benefits of integrating depression treatment into HIV care.
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DOI：
10.1080/09540120310001633994
发表时间：
2004-01-01
影响因子：
1.7
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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影响因子：
11.8
作者：
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