Multishot Diffusion-Weighted MRI of the Breast With Multiplexed Sensitivity Encoding (MUSE) and Shot Locally Low-Rank (Shot-LLR) Reconstructions.
Multishot Diffusion-Weighted MRI of the Breast With Multiplexed Sensitivity Encoding (MUSE) and Shot Locally Low-Rank (Shot-LLR) Reconstructions.
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基于多重灵敏度编码（MUSE）和局部低秩（Shot- llr）重建的乳腺多镜头扩散加权MRI。
DOI：
10.1002/jmri.27383
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Moran CJ
中科院分区：
文献类型：
--
作者：
Hu Y;Ikeda DM;Pittman SM;Samarawickrama D;Guidon A;Rosenberg J;Chen ST;Okamoto S;Daniel BL;Hargreaves BA;Moran CJ
扩散加权成像（DWI）已显示出在不注射造影剂的情况下筛查乳腺癌的前景，但图像失真和低空间分辨率限制了标准单次激发DWI。多激发DWI方法解决了这些限制，但引入了需要在重建期间校正的激发间相位变化。研究两种多激发DWI重建方法（多路敏感性编码（MUSE）和激发局部低秩（shot-LLR））与乳腺单激发DWI相比的性能。有前途。共有45名女性同意在有临床指征的乳腺MRI中添加多次激发DWI。通过平行成像重建的单次激发DWI、通过MUSE和激发LLR重建的4次或8次激发的多次激发DWI、3D T2加权成像和3 T下的对比增强MRI。三名设盲观察员对图像进行评分，包括1）一般图像质量（感知信噪比[SNR]、重影、失真），2）病变特征（识别和形态），3）感知分辨率。同时测量病灶的表观弥散系数（ADC），并比较两种方法的差异。图像质量特征和感知分辨率采用混合效应logistic回归进行评估。观察员之间的协议估计与Krippendorf的α使用线性加权。用直方图显示病变特征等级，并计算不同方法之间病变ADC的相关系数。与单次激发DWI相比，MUSE和shot-LLR图像被评定为具有显著更好的感知分辨率（P < 0.001）、更高的SNR（P < 0.005）和更低的失真水平（P < 0.05）。与MUSE（P < 0.001）和单次激发DWI（P < 0.001）相比，Shot-LLR显示重影伪影减少。与四次激发DWI相比，八次激发DWI的感知SNR和感知分辨率均有所改善（P < 0.005）。与乳腺中的单次激发DWI相比，多次激发DWI可提高分辨率并改善图像质量。Shot-LLR重建具有最小重影伪影的多激发DWI。多激发DWI在图像质量方面的改善随着激发次数的增加而增加。
Diffusion-weighted imaging (DWI) has shown promise to screen for breast cancer without a contrast injection, but image distortion and low spatial resolution limit standard single-shot DWI. Multishot DWI methods address these limitations but introduce shot-to-shot phase variations requiring correction during reconstruction. To investigate the performance of two multishot DWI reconstruction methods, multiplexed sensitivity encoding (MUSE) and shot locally low-rank (shot-LLR), compared to single-shot DWI in the breast. Prospective. A total of 45 women who consented to have multishot DWI added to a clinically indicated breast MRI. Single-shot DWI reconstructed by parallel imaging, multishot DWI with four or eight shots reconstructed by MUSE and shot-LLR, 3D T2-weighted imaging, and contrast-enhanced MRI at 3T. Three blinded observers scored images for 1) general image quality (perceived signal-to-noise ratio [SNR], ghosting, distortion), 2) lesion features (discernment and morphology), and 3) perceived resolution. Apparent diffusion coefficient (ADC) of the lesion was also measured and compared between methods. Image quality features and perceived resolution were assessed with a mixed-effects logistic regression. Agreement among observers was estimated with a Krippendorf’s alpha using linear weighting. Lesion feature ratings were visualized using histograms, and correlation coefficients of lesion ADC between different methods were calculated. MUSE and shot-LLR images were rated to have significantly better perceived resolution (P < 0.001), higher SNR (P < 0.005), and a lower level of distortion (P < 0.05) with respect to single-shot DWI. Shot-LLR showed reduced ghosting artifacts with respect to both MUSE (P < 0.001) and single-shot DWI (P < 0.001). Eight-shot DWI had improved perceived SNR and perceived resolution with respect to four-shot DWI (P < 0.005). Multishot DWI enables increased resolution and improved image quality with respect to single-shot DWI in the breast. Shot-LLR reconstructs multishot DWI with minimal ghosting artifacts. The improvement of multishot DWI in image quality increases with an increased number of shots.
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