The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations.
The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations.
复制标题
DOI：
10.1016/j.actbio.2016.12.054
复制
发表时间：
2017-04-15
影响因子：
9.7
通讯作者：
Nguyen TD
中科院分区：
文献类型：
--
作者：
Midgett DE;Pease ME;Jefferys JL;Patel M;Franck C;Quigley HA;Nguyen TD
本研究的目的是测量人类筛板（LC）的压力诱导变形反应，并分析其随年龄和解剖区域的变化。将来自6名人类供体的8只眼睛的后巩膜杯安装到定制的充气室上。使用激光扫描显微镜进行二次谐波产生（SHG），在5 mmHg至45 mmHg的压力下对LC后体积中的胶原结构进行成像。采用快速傅立叶迭代数字体积相关（DVC）算法对三维（3D）位移场进行分析。格林-拉格朗日应变张量和平面内的主和最大剪切应变的分量进行了评价，从DVC位移场的LC和鼻，颞，下，和上级象限周围的视网膜中央动脉和静脉的中心和周边区域。其中的主要发现是，年龄较大与较低的应变，最大剪切应变是在周边比中心区域，最大主应变是在鼻象限较低。LC的椭圆形状也是双轴应变比的预测。压力诱导的LC应变中的结构相关和结构相关变化可能有助于青光眼视神经损伤的易感性和严重性，并且区域变化可能解释青光眼LC中观察到的轴突损伤和组织重塑的进展。
The objective of this study was to measure the pressure-induced deformation response of the human lamina cribrosa (LC) and analyze for variations with age and anatomical region. The posterior scleral cup of 8 eyes from 6 human donors was mounted onto a custom inflation chamber. A laser-scanning microscope was used for second harmonic generation (SHG), imaging the collagen structure in the posterior volume of the LC at pressures from 5 mmHg to 45 mmHg. The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation (DVC) algorithm for the three dimensional (3D) displacement field. The components of the Green-Lagrange strain tensor and the in-plane principal and maximum shear strains were evaluated from the DVC displacement field for the central and peripheral regions of the LC and the nasal, temporal, inferior, and superior quadrants surrounding the central retinal artery and vein. Among the major findings were that older age was associated with lower strains, the maximum shear strain was larger in the peripheral than central region, and the maximum principal strain was lower in the nasal quadrant. The elliptical shape of the LC was also predictive of the biaxial strain ratio. Age-related and structure-related variations in the pressure-induced strains of the LC may contribute to the susceptibility and severity of optic nerve damage in glaucoma, and regional variations may explain the progression of axonal damage and tissue remodeling observed in the LC in glaucoma.
登录
查看更多内容
影响因子：
3.5
作者：
Fazio, Massimo A.;Grytz, Rafael;Morris, Jeffrey S.;Bruno, Luigi;Gardiner, Stuart K.;Girkin, Christopher A.;Downs, J. Crawford
通讯作者：
Downs, J. Crawford
影响因子：
3
作者：
Forsberg, F.;Mooser, R.;Wyss, P.
通讯作者：
Wyss, P.
影响因子：
4.4
作者：
Bellezza, AJ;Rintalan, CJ;Burgoyne, CF
通讯作者：
Burgoyne, CF
影响因子：
13.7
作者：
Agoumi, Younes;Sharpe, Glen P.;Chauhan, Balwantray C.
通讯作者：
Chauhan, Balwantray C.
影响因子：
4.4
作者：
Fatehee, Naeem;Yu, Paula K.;Yu, Dao-Yi
通讯作者：
Yu, Dao-Yi